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Diagnostic Value of Fecal Calprotectin in Patient with Ulcerative Colitis

BACKGROUND: Ulcerative colitis (UC) is characterized by recurrent episodes of inflammation limited to the mucosal layer of the colon. Calprotectin is a zinc and calcium binding protein derived from neutrophils and monocytes. It is easily detectable in tissue samples, body fluids, and stools, which m...

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Autores principales: Zamani, Hamed, Barzin, Gilda, Yousefinia, Mahsa, Mohammadkhani, Ashraf, Ostovaneh, Mohammad Reza, Sharifi, Amir Houshang, Tayebi, Sirous, Malekzadeh, Reza, Ansari, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Association of Gastroerterology and Hepatology 2013
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990145/
https://www.ncbi.nlm.nih.gov/pubmed/24829673
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author Zamani, Hamed
Barzin, Gilda
Yousefinia, Mahsa
Mohammadkhani, Ashraf
Ostovaneh, Mohammad Reza
Sharifi, Amir Houshang
Tayebi, Sirous
Malekzadeh, Reza
Ansari, Reza
author_facet Zamani, Hamed
Barzin, Gilda
Yousefinia, Mahsa
Mohammadkhani, Ashraf
Ostovaneh, Mohammad Reza
Sharifi, Amir Houshang
Tayebi, Sirous
Malekzadeh, Reza
Ansari, Reza
author_sort Zamani, Hamed
collection PubMed
description BACKGROUND: Ulcerative colitis (UC) is characterized by recurrent episodes of inflammation limited to the mucosal layer of the colon. Calprotectin is a zinc and calcium binding protein derived from neutrophils and monocytes. It is easily detectable in tissue samples, body fluids, and stools, which makes it a potentially valuable marker of inflammation. The aim of the current study is to evaluate the value of fecal calprotectin (FC) as a marker of disease activity in patients with UC. METHODS: Seventy three eligible subjects underwent ileocolonoscopy and multiple biopsies were obtained from different parts of the colon and terminal ileum. All patients underwent blood and stool sampling as well as an interview to assess the disease severity utilizing ulcerative colitis activity index (UCAI), subjectively. The diagnostic value of the FC in comparison with Mayo disease activity index as the gold standard technique, was then evaluated. RESULTS: Mean FC level increased linearly according to Mayo disease activity index (r=0.44, p<0.001) and was significantly different between levels of Mayo disease activity index (p=0.003). In multivariate analysis, Mayo disease activity index, positive CRP and ESR were associated with FC level. FC level > 21.4 ng/ml was able to discriminate between active and inactive phases of UC according to Mayo disease activity index>2 with 72.3% sensitivity and 73.1% specificity. The combination of FC > 21.4 ng/ml and UCAI score of 7 had a 46.8% sensitivity and 88% specificity to diagnose Mayo disease activity index >2. Furthermore, FC level <21.4 ng/ml in combination with UCAI score of <3 showed a highly considerable specificity of 98% to discriminate the remission phase of UC (Mayo disease activity index <2), although with a low sensitivity (31%). CONCLUSION: FC appears to be a non-invasive biomarker with moderate accuracy to discriminate the active phase of inflammatory bowel disease (IBD). The value of FC especially in combination with UCAI is highly considerable to rule out the Mayo disease activity index >2.
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spelling pubmed-39901452014-05-14 Diagnostic Value of Fecal Calprotectin in Patient with Ulcerative Colitis Zamani, Hamed Barzin, Gilda Yousefinia, Mahsa Mohammadkhani, Ashraf Ostovaneh, Mohammad Reza Sharifi, Amir Houshang Tayebi, Sirous Malekzadeh, Reza Ansari, Reza Middle East J Dig Dis Original Article BACKGROUND: Ulcerative colitis (UC) is characterized by recurrent episodes of inflammation limited to the mucosal layer of the colon. Calprotectin is a zinc and calcium binding protein derived from neutrophils and monocytes. It is easily detectable in tissue samples, body fluids, and stools, which makes it a potentially valuable marker of inflammation. The aim of the current study is to evaluate the value of fecal calprotectin (FC) as a marker of disease activity in patients with UC. METHODS: Seventy three eligible subjects underwent ileocolonoscopy and multiple biopsies were obtained from different parts of the colon and terminal ileum. All patients underwent blood and stool sampling as well as an interview to assess the disease severity utilizing ulcerative colitis activity index (UCAI), subjectively. The diagnostic value of the FC in comparison with Mayo disease activity index as the gold standard technique, was then evaluated. RESULTS: Mean FC level increased linearly according to Mayo disease activity index (r=0.44, p<0.001) and was significantly different between levels of Mayo disease activity index (p=0.003). In multivariate analysis, Mayo disease activity index, positive CRP and ESR were associated with FC level. FC level > 21.4 ng/ml was able to discriminate between active and inactive phases of UC according to Mayo disease activity index>2 with 72.3% sensitivity and 73.1% specificity. The combination of FC > 21.4 ng/ml and UCAI score of 7 had a 46.8% sensitivity and 88% specificity to diagnose Mayo disease activity index >2. Furthermore, FC level <21.4 ng/ml in combination with UCAI score of <3 showed a highly considerable specificity of 98% to discriminate the remission phase of UC (Mayo disease activity index <2), although with a low sensitivity (31%). CONCLUSION: FC appears to be a non-invasive biomarker with moderate accuracy to discriminate the active phase of inflammatory bowel disease (IBD). The value of FC especially in combination with UCAI is highly considerable to rule out the Mayo disease activity index >2. Iranian Association of Gastroerterology and Hepatology 2013-04 /pmc/articles/PMC3990145/ /pubmed/24829673 Text en © 2013 by Middle East Journal of Digestive Diseases This work is published by Middle East Journal of Digestive Diseases as an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-sa/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
Zamani, Hamed
Barzin, Gilda
Yousefinia, Mahsa
Mohammadkhani, Ashraf
Ostovaneh, Mohammad Reza
Sharifi, Amir Houshang
Tayebi, Sirous
Malekzadeh, Reza
Ansari, Reza
Diagnostic Value of Fecal Calprotectin in Patient with Ulcerative Colitis
title Diagnostic Value of Fecal Calprotectin in Patient with Ulcerative Colitis
title_full Diagnostic Value of Fecal Calprotectin in Patient with Ulcerative Colitis
title_fullStr Diagnostic Value of Fecal Calprotectin in Patient with Ulcerative Colitis
title_full_unstemmed Diagnostic Value of Fecal Calprotectin in Patient with Ulcerative Colitis
title_short Diagnostic Value of Fecal Calprotectin in Patient with Ulcerative Colitis
title_sort diagnostic value of fecal calprotectin in patient with ulcerative colitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990145/
https://www.ncbi.nlm.nih.gov/pubmed/24829673
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