Reduced repair capacity of a DNA clustered damage site comprised of 8-oxo-7,8-dihydro-2′-deoxyguanosine and 2-deoxyribonolactone results in an increased mutagenic potential of these lesions

A signature of ionizing radiation is the induction of DNA clustered damaged sites. Non-double strand break (DSB) clustered damage has been shown to compromise the base excision repair pathway, extending the lifetimes of the lesions within the cluster, compared to isolated lesions. This increases the...

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Detalles Bibliográficos
Autores principales: Cunniffe, Siobhan, O’Neill, Peter, Greenberg, Marc M., Lomax, Martine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990186/
https://www.ncbi.nlm.nih.gov/pubmed/24631220
http://dx.doi.org/10.1016/j.mrfmmm.2014.02.005

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