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Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure (Review)

Regucalcin was first identified in 1978 as a regulatory protein of Ca(2+) signaling in liver cells. Regucalcin was shown to play a multifunctional role in cell regulation, such as maintainance of intracellular Ca(2+) homeostasis and suppression of signal transduction, protein synthesis, nuclear func...

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Autor principal: YAMAGUCHI, MASAYOSHI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990221/
https://www.ncbi.nlm.nih.gov/pubmed/24748964
http://dx.doi.org/10.3892/br.2014.245
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author YAMAGUCHI, MASAYOSHI
author_facet YAMAGUCHI, MASAYOSHI
author_sort YAMAGUCHI, MASAYOSHI
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description Regucalcin was first identified in 1978 as a regulatory protein of Ca(2+) signaling in liver cells. Regucalcin was shown to play a multifunctional role in cell regulation, such as maintainance of intracellular Ca(2+) homeostasis and suppression of signal transduction, protein synthesis, nuclear function, cell proliferation and apoptosis in various types of cells and tissues. Cardiac excitation-contraction coupling is based on the regulation of intracellular Ca(2+) concentration by the Ca(2+) pump in the sarcoplasmic reticulum of heart muscle cells. Regucalcin, which is expressed in the heart, was found to increase rat heart sarcoplasmic reticulum Ca(2+)-ATPase activity and ATP-dependent Ca(2+) uptake and mitochondrial Ca(2+)-ATPase activity. Regucalcin was also shown to suppress Ca(2+)-dependent protein tyrosine phosphatase, Ca(2+)/calmodulin-dependent protein phosphatase (calcineurin) and nitric oxide (NO) synthase activity in the heart cytoplasm. Moreover, regucalcin was found to activate superoxide dismutase (SOD), which plays a significant role in the prevention of cell death and apoptosis in the heart. Regucalcin may be a key molecule in heart muscle cell regulation through Ca(2+) signaling. Regucalcin may also play a pathophysiological role in heart failure. The aim of this study was to review the recent findings regarding the role of regucalcin in Ca(2+) signaling in the heart.
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spelling pubmed-39902212014-04-18 Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure (Review) YAMAGUCHI, MASAYOSHI Biomed Rep Articles Regucalcin was first identified in 1978 as a regulatory protein of Ca(2+) signaling in liver cells. Regucalcin was shown to play a multifunctional role in cell regulation, such as maintainance of intracellular Ca(2+) homeostasis and suppression of signal transduction, protein synthesis, nuclear function, cell proliferation and apoptosis in various types of cells and tissues. Cardiac excitation-contraction coupling is based on the regulation of intracellular Ca(2+) concentration by the Ca(2+) pump in the sarcoplasmic reticulum of heart muscle cells. Regucalcin, which is expressed in the heart, was found to increase rat heart sarcoplasmic reticulum Ca(2+)-ATPase activity and ATP-dependent Ca(2+) uptake and mitochondrial Ca(2+)-ATPase activity. Regucalcin was also shown to suppress Ca(2+)-dependent protein tyrosine phosphatase, Ca(2+)/calmodulin-dependent protein phosphatase (calcineurin) and nitric oxide (NO) synthase activity in the heart cytoplasm. Moreover, regucalcin was found to activate superoxide dismutase (SOD), which plays a significant role in the prevention of cell death and apoptosis in the heart. Regucalcin may be a key molecule in heart muscle cell regulation through Ca(2+) signaling. Regucalcin may also play a pathophysiological role in heart failure. The aim of this study was to review the recent findings regarding the role of regucalcin in Ca(2+) signaling in the heart. D.A. Spandidos 2014-05 2014-03-05 /pmc/articles/PMC3990221/ /pubmed/24748964 http://dx.doi.org/10.3892/br.2014.245 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
YAMAGUCHI, MASAYOSHI
Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure (Review)
title Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure (Review)
title_full Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure (Review)
title_fullStr Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure (Review)
title_full_unstemmed Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure (Review)
title_short Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure (Review)
title_sort regulatory role of regucalcin in heart calcium signaling: insight into cardiac failure (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990221/
https://www.ncbi.nlm.nih.gov/pubmed/24748964
http://dx.doi.org/10.3892/br.2014.245
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