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Phylogenetic Quantification of Intra-tumour Heterogeneity

Intra-tumour genetic heterogeneity is the result of ongoing evolutionary change within each cancer. The expansion of genetically distinct sub-clonal populations may explain the emergence of drug resistance, and if so, would have prognostic and predictive utility. However, methods for objectively qua...

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Detalles Bibliográficos
Autores principales:	Schwarz, Roland F., Trinh, Anne, Sipos, Botond, Brenton, James D., Goldman, Nick, Markowetz, Florian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990475/ https://www.ncbi.nlm.nih.gov/pubmed/24743184 http://dx.doi.org/10.1371/journal.pcbi.1003535

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