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Identification of Logic Relationships between Genes and Subtypes of Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) has two major subtypes: adenocarcinoma (AC) and squamous cell carcinoma (SCC). The diagnosis and treatment of NSCLC are hindered by the limited knowledge about the pathogenesis mechanisms of subtypes of NSCLC. It is necessary to research the molecular mechanisms re...

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Detalles Bibliográficos
Autores principales: Su, Yansen, Pan, Linqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990524/
https://www.ncbi.nlm.nih.gov/pubmed/24743794
http://dx.doi.org/10.1371/journal.pone.0094644
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author Su, Yansen
Pan, Linqiang
author_facet Su, Yansen
Pan, Linqiang
author_sort Su, Yansen
collection PubMed
description Non-small cell lung cancer (NSCLC) has two major subtypes: adenocarcinoma (AC) and squamous cell carcinoma (SCC). The diagnosis and treatment of NSCLC are hindered by the limited knowledge about the pathogenesis mechanisms of subtypes of NSCLC. It is necessary to research the molecular mechanisms related with AC and SCC. In this work, we improved the logic analysis algorithm to mine the sufficient and necessary conditions for the presence states (presence or absence) of phenotypes. We applied our method to AC and SCC specimens, and identified [Image: see text] lower and [Image: see text] higher logic relationships between genes and two subtypes of NSCLC. The discovered relationships were independent of specimens selected, and their significance was validated by statistic test. Compared with the two earlier methods (the non-negative matrix factorization method and the relevance analysis method), the current method outperformed these methods in the recall rate and classification accuracy on NSCLC and normal specimens. We obtained [Image: see text] biomarkers. Among [Image: see text] biomarkers, [Image: see text] genes have been used to distinguish AC from SCC in practice, and other six genes were newly discovered biomarkers for distinguishing subtypes. Furthermore, NKX2-1 has been considered as a molecular target for the targeted therapy of AC, and [Image: see text] other genes may be novel molecular targets. By gene ontology analysis, we found that two biological processes (‘epidermis development’ and ‘cell adhesion’) were closely related with the tumorigenesis of subtypes of NSCLC. More generally, the current method could be extended to other complex diseases for distinguishing subtypes and detecting the molecular targets for targeted therapy.
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spelling pubmed-39905242014-04-21 Identification of Logic Relationships between Genes and Subtypes of Non-Small Cell Lung Cancer Su, Yansen Pan, Linqiang PLoS One Research Article Non-small cell lung cancer (NSCLC) has two major subtypes: adenocarcinoma (AC) and squamous cell carcinoma (SCC). The diagnosis and treatment of NSCLC are hindered by the limited knowledge about the pathogenesis mechanisms of subtypes of NSCLC. It is necessary to research the molecular mechanisms related with AC and SCC. In this work, we improved the logic analysis algorithm to mine the sufficient and necessary conditions for the presence states (presence or absence) of phenotypes. We applied our method to AC and SCC specimens, and identified [Image: see text] lower and [Image: see text] higher logic relationships between genes and two subtypes of NSCLC. The discovered relationships were independent of specimens selected, and their significance was validated by statistic test. Compared with the two earlier methods (the non-negative matrix factorization method and the relevance analysis method), the current method outperformed these methods in the recall rate and classification accuracy on NSCLC and normal specimens. We obtained [Image: see text] biomarkers. Among [Image: see text] biomarkers, [Image: see text] genes have been used to distinguish AC from SCC in practice, and other six genes were newly discovered biomarkers for distinguishing subtypes. Furthermore, NKX2-1 has been considered as a molecular target for the targeted therapy of AC, and [Image: see text] other genes may be novel molecular targets. By gene ontology analysis, we found that two biological processes (‘epidermis development’ and ‘cell adhesion’) were closely related with the tumorigenesis of subtypes of NSCLC. More generally, the current method could be extended to other complex diseases for distinguishing subtypes and detecting the molecular targets for targeted therapy. Public Library of Science 2014-04-17 /pmc/articles/PMC3990524/ /pubmed/24743794 http://dx.doi.org/10.1371/journal.pone.0094644 Text en © 2014 Su, Pan http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Su, Yansen
Pan, Linqiang
Identification of Logic Relationships between Genes and Subtypes of Non-Small Cell Lung Cancer
title Identification of Logic Relationships between Genes and Subtypes of Non-Small Cell Lung Cancer
title_full Identification of Logic Relationships between Genes and Subtypes of Non-Small Cell Lung Cancer
title_fullStr Identification of Logic Relationships between Genes and Subtypes of Non-Small Cell Lung Cancer
title_full_unstemmed Identification of Logic Relationships between Genes and Subtypes of Non-Small Cell Lung Cancer
title_short Identification of Logic Relationships between Genes and Subtypes of Non-Small Cell Lung Cancer
title_sort identification of logic relationships between genes and subtypes of non-small cell lung cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990524/
https://www.ncbi.nlm.nih.gov/pubmed/24743794
http://dx.doi.org/10.1371/journal.pone.0094644
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