A Site-Specific, Single-Copy Transgenesis Strategy to Identify 5′ Regulatory Sequences of the Mouse Testis-Determining Gene Sry

The Y-chromosomal gene SRY acts as the primary trigger for male sex determination in mammalian embryos. Correct regulation of SRY is critical: aberrant timing or level of Sry expression is known to disrupt testis development in mice and we hypothesize that mutations that affect regulation of human S...

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Detalles Bibliográficos
Autores principales: Quinn, Alexander, Kashimada, Kenichi, Davidson, Tara-Lynne, Ng, Ee Ting, Chawengsaksophak, Kallayanee, Bowles, Josephine, Koopman, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990564/
https://www.ncbi.nlm.nih.gov/pubmed/24743337
http://dx.doi.org/10.1371/journal.pone.0094813

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