Potent Dengue Virus Neutralization by a Therapeutic Antibody with Low Monovalent Affinity Requires Bivalent Engagement

We recently described our most potently neutralizing monoclonal antibody, E106, which protected against lethal Dengue virus type 1 (DENV-1) infection in mice. To further understand its functional properties, we determined the crystal structure of E106 Fab in complex with domain III (DIII) of DENV-1...

Descripción completa

Detalles Bibliográficos
Autores principales: Edeling, Melissa A., Austin, S. Kyle, Shrestha, Bimmi, Dowd, Kimberly A., Mukherjee, Swati, Nelson, Christopher A., Johnson, Syd, Mabila, Manu N., Christian, Elizabeth A., Rucker, Joseph, Pierson, Theodore C., Diamond, Michael S., Fremont, Daved H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990716/
https://www.ncbi.nlm.nih.gov/pubmed/24743696
http://dx.doi.org/10.1371/journal.ppat.1004072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990716/
https://www.ncbi.nlm.nih.gov/pubmed/24743696
http://dx.doi.org/10.1371/journal.ppat.1004072

Ejemplares similares