Deficient IFN Signaling by Myeloid Cells Leads to MAVS-Dependent Virus-Induced Sepsis

The type I interferon (IFN) signaling response limits infection of many RNA and DNA viruses. To define key cell types that require type I IFN signaling to orchestrate immunity against West Nile virus (WNV), we infected mice with conditional deletions of the type I IFN receptor (IFNAR) gene. Deletion...

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Detalles Bibliográficos
Autores principales: Pinto, Amelia K., Ramos, Hilario J., Wu, Xiaobo, Aggarwal, Shilpa, Shrestha, Bimmi, Gorman, Matthew, Kim, Kristin Y., Suthar, Mehul S., Atkinson, John P., Gale Jr, Michael, Diamond, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990718/
https://www.ncbi.nlm.nih.gov/pubmed/24743949
http://dx.doi.org/10.1371/journal.ppat.1004086

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