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Towards a safe and effective chlamydial vaccine: Lessons from the eye

As well as being the most common bacterial sexually transmitted infection, Chlamydia trachomatis (Ct) is the leading infectious cause of blindness. The pathogenesis of ocular chlamydial infection (trachoma) is similar to that of genital infection. In the 1960s the efficacy of Ct vaccines against ocu...

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Autores principales: Mabey, David C.W., Hu, Victor, Bailey, Robin L., Burton, Matthew J., Holland, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991328/
https://www.ncbi.nlm.nih.gov/pubmed/24606636
http://dx.doi.org/10.1016/j.vaccine.2013.10.016
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author Mabey, David C.W.
Hu, Victor
Bailey, Robin L.
Burton, Matthew J.
Holland, Martin J.
author_facet Mabey, David C.W.
Hu, Victor
Bailey, Robin L.
Burton, Matthew J.
Holland, Martin J.
author_sort Mabey, David C.W.
collection PubMed
description As well as being the most common bacterial sexually transmitted infection, Chlamydia trachomatis (Ct) is the leading infectious cause of blindness. The pathogenesis of ocular chlamydial infection (trachoma) is similar to that of genital infection. In the 1960s the efficacy of Ct vaccines against ocular infection was evaluated in major field trials in Saudi Arabia, Taiwan, The Gambia, India and Ethiopia. These trials showed that it was possible to induce short term immunity to ocular infection, and to reduce the incidence of inflammatory trachoma, by parenteral immunisation with killed or live whole organism vaccines. In one study, it was also shown that the incidence of scarring sequelae was reduced in vaccinated children. Detailed studies in non-human primates conducted at this time suggested that vaccination could lead to more severe inflammatory disease on subsequent challenge. Since that time there have been many studies on the immunological correlates of protective immunity and immunopathology in ocular Ct infection in humans and non-human primates, and on host genetic polymorphisms associated with protection from adverse sequelae. These have provided important information to guide the development and evaluation of a human Ct vaccine.
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spelling pubmed-39913282014-04-18 Towards a safe and effective chlamydial vaccine: Lessons from the eye Mabey, David C.W. Hu, Victor Bailey, Robin L. Burton, Matthew J. Holland, Martin J. Vaccine Article As well as being the most common bacterial sexually transmitted infection, Chlamydia trachomatis (Ct) is the leading infectious cause of blindness. The pathogenesis of ocular chlamydial infection (trachoma) is similar to that of genital infection. In the 1960s the efficacy of Ct vaccines against ocular infection was evaluated in major field trials in Saudi Arabia, Taiwan, The Gambia, India and Ethiopia. These trials showed that it was possible to induce short term immunity to ocular infection, and to reduce the incidence of inflammatory trachoma, by parenteral immunisation with killed or live whole organism vaccines. In one study, it was also shown that the incidence of scarring sequelae was reduced in vaccinated children. Detailed studies in non-human primates conducted at this time suggested that vaccination could lead to more severe inflammatory disease on subsequent challenge. Since that time there have been many studies on the immunological correlates of protective immunity and immunopathology in ocular Ct infection in humans and non-human primates, and on host genetic polymorphisms associated with protection from adverse sequelae. These have provided important information to guide the development and evaluation of a human Ct vaccine. Elsevier Science 2014-03-20 /pmc/articles/PMC3991328/ /pubmed/24606636 http://dx.doi.org/10.1016/j.vaccine.2013.10.016 Text en © 2013 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Mabey, David C.W.
Hu, Victor
Bailey, Robin L.
Burton, Matthew J.
Holland, Martin J.
Towards a safe and effective chlamydial vaccine: Lessons from the eye
title Towards a safe and effective chlamydial vaccine: Lessons from the eye
title_full Towards a safe and effective chlamydial vaccine: Lessons from the eye
title_fullStr Towards a safe and effective chlamydial vaccine: Lessons from the eye
title_full_unstemmed Towards a safe and effective chlamydial vaccine: Lessons from the eye
title_short Towards a safe and effective chlamydial vaccine: Lessons from the eye
title_sort towards a safe and effective chlamydial vaccine: lessons from the eye
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991328/
https://www.ncbi.nlm.nih.gov/pubmed/24606636
http://dx.doi.org/10.1016/j.vaccine.2013.10.016
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