Cargando…

IL-2 analogues: novel agents circumventing the expansion of T regulatory cells while promoting NK cell activation during IL-2 therapy

Detalles Bibliográficos
Autores principales:	Sim, Geok Choo, Grimm, Elizabeth, Dai, ZhiMin, Overwijk, Willem, Hwu, Patrick, Radvanyi, Laszlo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Poster Presentation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991370/ http://dx.doi.org/10.1186/2051-1426-1-S1-P89

Ejemplares similares

Defective STAT1 activation associated with impaired IFN-γ production in NK and T lymphocytes from metastatic melanoma patients treated with IL-2
por: Sim, Geok Choo, et al.
Publicado: (2016)

IL-1-dependent cartilage damage in a macrophage-driven arthritis model can be circumvented by T cell IL-17
por: Koenders, MI, et al.
Publicado: (2004)

Myc controls NK cell development, IL-15-driven expansion, and translational machinery
por: Khameneh, Hanif J, et al.
Publicado: (2023)

Membrane bound IL-21 based NK cell feeder cells drive robust expansion and metabolic activation of NK cells
por: Ojo, Evelyn O., et al.
Publicado: (2019)

IL-2–dependent adaptive control of NK cell homeostasis
por: Gasteiger, Georg, et al.
Publicado: (2013)

Improving NK cell function in multiple myeloma with NKTR-255, a novel polymer-conjugated human IL-15
por: Fernandez, Rafael Alonso, et al.
Publicado: (2022)

TNF dependency of IL-17-induced joint pathology can be circumvented by Toll-like receptor-2 signaling
por: Van den Berg, W, et al.
Publicado: (2003)

A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells
por: Harris, Katherine E., et al.
Publicado: (2021)

Sialylation of Human Natural Killer (NK) Cells Is Regulated by IL-2
por: Rosenstock, Philip, et al.
Publicado: (2020)

Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice
por: Matsuda, Masashi, et al.
Publicado: (2019)

NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation
por: Clark, Sarah E., et al.
Publicado: (2019)

A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation
por: Granucci, Francesca, et al.
Publicado: (2004)

Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2
por: Sitrin, Jonathan, et al.
Publicado: (2013)

Immediate triggering of 4-1BB co-stimulation during initiation of tumor-infiltrating lymphocyte (TIL) expansion from melanoma tumors accelerates CD8+ T-cell outgrowth and tumor specificity
por: Chacon, Jessica, et al.
Publicado: (2013)

IL-1 receptor antagonist restores IL-18 NK cell axis in systemic JIA
por: Vastert, Sebastiaan J, et al.
Publicado: (2012)

IL-15 Promotes Polyfunctional NK Cell Responses to Influenza by Boosting IL-12 Production
por: Wagstaffe, Helen R., et al.
Publicado: (2018)

IL‐18‐induced expression of high‐affinity IL‐2R on murine NK cells is essential for NK‐cell IFN‐γ production during murine Plasmodium yoelii infection
por: Stegmann, Kerstin A., et al.
Publicado: (2015)

IL-21-dependent expansion of memory-like NK cells enhances protective immune responses against Mycobacterium tuberculosis
por: Venkatasubramanian, Sambasivan, et al.
Publicado: (2016)

IL-18, but not IL-15, contributes to the IL-12-dependent induction of NK-cell effector functions by Leishmania infantum in vivo
por: Haeberlein, Simone, et al.
Publicado: (2010)

An In-Vitro Study of the Expansion and Transcriptomics of CD(4+) and CD(8+) Naïve and Memory T Cells Stimulated by IL-2, IL-7 and IL-15
por: Hopkins, Brooks, et al.
Publicado: (2022)

IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
por: Gasteiger, Georg, et al.
Publicado: (2013)

Expansion of Human NK Cells Using K562 Cells Expressing OX40 Ligand and Short Exposure to IL-21
por: Kweon, SoonHo, et al.
Publicado: (2019)

Hypoxia Induced Impairment of NK Cell Cytotoxicity against Multiple Myeloma Can Be Overcome by IL-2 Activation of the NK Cells
por: Sarkar, Subhashis, et al.
Publicado: (2013)

NK cell HMGB1 mediates IL-2-induced “systemic autophagic” toxicity
por: Li, Guanqiao, et al.
Publicado: (2013)

TL1A Selectively Enhances IL-12/IL-18-Induced NK Cell Cytotoxicity against NK-Resistant Tumor Targets
por: Heidemann, Stephanie C., et al.
Publicado: (2010)

Phenotypic and Functional Dysregulated Blood NK Cells in Colorectal Cancer Patients Can Be Activated by Cetuximab Plus IL-2 or IL-15
por: Rocca, Yamila Sol, et al.
Publicado: (2016)

Enhanced development of functional human NK cells in NOD‐ scid‐IL2rg(null) mice expressing human IL15
por: Aryee, Ken‐Edwin, et al.
Publicado: (2022)

An Il12-Il2-Antibody Fusion Protein Targeting Hodgkin's Lymphoma Cells Potentiates Activation Of Nk And T Cells For An Anti-Tumor Attack
por: Jahn, Tobias, et al.
Publicado: (2012)

Regulation of NK Cell Activation and Effector Functions by the IL-12 Family of Cytokines: The Case of IL-27
por: Zwirner, Norberto Walter, et al.
Publicado: (2017)

Sarcoma IL-12 overexpression facilitates NK cell immunomodulation
por: Rademacher, Mary Jo, et al.
Publicado: (2021)

Multi-cellular natural killer (NK) cell clusters enhance NK cell activation through localizing IL-2 within the cluster
por: Kim, Miju, et al.
Publicado: (2017)

NK cell-derived IL-10 is critical for DC-NK cell dialogue at the maternal-fetal interface
por: Blois, Sandra M., et al.
Publicado: (2017)

Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection
por: Lee, Seung-Hwan, et al.
Publicado: (2009)

Synergy of IL-21 and IL-15 in regulating CD8(+) T cell expansion and function
por: Zeng, Rong, et al.
Publicado: (2005)

Co-Expression of an IL-15 Superagonist Facilitates Self-Enrichment of GD(2)-Targeted CAR-NK Cells and Mediates Potent Cell Killing in the Absence of IL-2
por: Bodden, Malena, et al.
Publicado: (2023)

NKG2D is a Key Receptor for Recognition of Bladder Cancer Cells by IL-2-Activated NK Cells and BCG Promotes NK Cell Activation
por: García-Cuesta, Eva María, et al.
Publicado: (2015)

Salmonella Induced IL-23 and IL-1β Allow for IL-12 Production by Monocytes and Mϕ1 through Induction of IFN-γ in CD56(+) NK/NK-Like T Cells
por: van de Wetering, Diederik, et al.
Publicado: (2009)

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
por: Niogret, Charlène, et al.
Publicado: (2019)

Circumventing the Greatwall
por: Short, Ben
Publicado: (2014)

Induction of systemic anti-melanoma immunity through intratumoral TLR-7/8 activation
por: Singh, Manisha, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_vvl6claiu607nb981dvi2uh88v