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FIZZ1 promotes airway remodeling through the PI3K/Akt signaling pathway in asthma
Found in inflammatory zone 1 (FIZZ1) plays a vital role in pulmonary inflammation and angiogenesis. In addition, FIZZ1 plays a role in the early stages of airway remodeling in asthma by increasing the expression of α smooth muscle actin (α-SMA) and type I collagen. However, the role of FIZZ1 in the...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991528/ https://www.ncbi.nlm.nih.gov/pubmed/24940423 http://dx.doi.org/10.3892/etm.2014.1580 |
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author | WANG, JUNFEI LI, FEI YANG, MENGMENG WU, JINXIANG ZHAO, JIPING GONG, WENBIN LIU, WEN BI, WENXIANG DONG, LIANG |
author_facet | WANG, JUNFEI LI, FEI YANG, MENGMENG WU, JINXIANG ZHAO, JIPING GONG, WENBIN LIU, WEN BI, WENXIANG DONG, LIANG |
author_sort | WANG, JUNFEI |
collection | PubMed |
description | Found in inflammatory zone 1 (FIZZ1) plays a vital role in pulmonary inflammation and angiogenesis. In addition, FIZZ1 plays a role in the early stages of airway remodeling in asthma by increasing the expression of α smooth muscle actin (α-SMA) and type I collagen. However, the role of FIZZ1 in the airway remodeling of asthma remains unclear. In the present study, FIZZ1 was identified to be upregulated in ovalbumin (OVA)-induced asthmatic mice, along with phosphorylated protein kinase B (Akt). Following FIZZ1 recombinant protein co-culture in the murine lung epithelial-cell line, Akt phosphorylation was upregulated, however, following transfection with FIZZ1-small hairpin RNA, the phosphorylation levels were decreased. The variation in α-SMA and type I collagen expression levels was consistent with the Akt phosphorylation levels. Intratracheal administration of LY294002 and Akt inhibitor IV to the asthmatic mice was capable of reducing airway inflammation, downregulating the expression of α-SMA, type I collagen and fibronectin-1 and increasing the expression of E-cadherin. In conclusion, the present study demonstrated that FIZZ1 promoted airway remodeling in asthma via the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. Blocking the PI3K/Akt signaling pathway may attenuate the early stages of airway remodeling induced by OVA by regulating the abnormal process of epithelial-mesenchymal transition. |
format | Online Article Text |
id | pubmed-3991528 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-39915282014-06-17 FIZZ1 promotes airway remodeling through the PI3K/Akt signaling pathway in asthma WANG, JUNFEI LI, FEI YANG, MENGMENG WU, JINXIANG ZHAO, JIPING GONG, WENBIN LIU, WEN BI, WENXIANG DONG, LIANG Exp Ther Med Articles Found in inflammatory zone 1 (FIZZ1) plays a vital role in pulmonary inflammation and angiogenesis. In addition, FIZZ1 plays a role in the early stages of airway remodeling in asthma by increasing the expression of α smooth muscle actin (α-SMA) and type I collagen. However, the role of FIZZ1 in the airway remodeling of asthma remains unclear. In the present study, FIZZ1 was identified to be upregulated in ovalbumin (OVA)-induced asthmatic mice, along with phosphorylated protein kinase B (Akt). Following FIZZ1 recombinant protein co-culture in the murine lung epithelial-cell line, Akt phosphorylation was upregulated, however, following transfection with FIZZ1-small hairpin RNA, the phosphorylation levels were decreased. The variation in α-SMA and type I collagen expression levels was consistent with the Akt phosphorylation levels. Intratracheal administration of LY294002 and Akt inhibitor IV to the asthmatic mice was capable of reducing airway inflammation, downregulating the expression of α-SMA, type I collagen and fibronectin-1 and increasing the expression of E-cadherin. In conclusion, the present study demonstrated that FIZZ1 promoted airway remodeling in asthma via the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. Blocking the PI3K/Akt signaling pathway may attenuate the early stages of airway remodeling induced by OVA by regulating the abnormal process of epithelial-mesenchymal transition. D.A. Spandidos 2014-05 2014-02-24 /pmc/articles/PMC3991528/ /pubmed/24940423 http://dx.doi.org/10.3892/etm.2014.1580 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles WANG, JUNFEI LI, FEI YANG, MENGMENG WU, JINXIANG ZHAO, JIPING GONG, WENBIN LIU, WEN BI, WENXIANG DONG, LIANG FIZZ1 promotes airway remodeling through the PI3K/Akt signaling pathway in asthma |
title | FIZZ1 promotes airway remodeling through the PI3K/Akt signaling pathway in asthma |
title_full | FIZZ1 promotes airway remodeling through the PI3K/Akt signaling pathway in asthma |
title_fullStr | FIZZ1 promotes airway remodeling through the PI3K/Akt signaling pathway in asthma |
title_full_unstemmed | FIZZ1 promotes airway remodeling through the PI3K/Akt signaling pathway in asthma |
title_short | FIZZ1 promotes airway remodeling through the PI3K/Akt signaling pathway in asthma |
title_sort | fizz1 promotes airway remodeling through the pi3k/akt signaling pathway in asthma |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991528/ https://www.ncbi.nlm.nih.gov/pubmed/24940423 http://dx.doi.org/10.3892/etm.2014.1580 |
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