A Novel Highly Potent Autotaxin/ENPP2 Inhibitor Produces Prolonged Decreases in Plasma Lysophosphatidic Acid Formation In Vivo and Regulates Urethral Tension

Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), is a secreted enzyme that has lysophospholipase D activity, which converts lysophosphatidylcholine to bioactive lysophosphatidic acid. Lysophosphatidic acid activates at least six G-protein coupled recpetors, which...

Descripción completa

Detalles Bibliográficos
Autores principales: Saga, Hiroshi, Ohhata, Akira, Hayashi, Akio, Katoh, Makoto, Maeda, Tatsuo, Mizuno, Hirotaka, Takada, Yuka, Komichi, Yuka, Ota, Hiroto, Matsumura, Naoya, Shibaya, Masami, Sugiyama, Tetsuya, Nakade, Shinji, Kishikawa, Katsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991570/
https://www.ncbi.nlm.nih.gov/pubmed/24747415
http://dx.doi.org/10.1371/journal.pone.0093230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991570/
https://www.ncbi.nlm.nih.gov/pubmed/24747415
http://dx.doi.org/10.1371/journal.pone.0093230

Ejemplares similares