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Characteristics, In-Hospital and Long-Term Clinical Outcomes of Nonagenarian Compared with Octogenarian Acute Myocardial Infarction Patients
We compared clinical characteristics, management, and clinical outcomes of nonagenarian acute myocardial infarction (AMI) patients (n=270, 92.3±2.3 yr old) with octogenarian AMI patients (n=2,145, 83.5±2.7 yr old) enrolled in Korean AMI Registry (KAMIR). Nonagenarians were less likely to have hypert...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991796/ https://www.ncbi.nlm.nih.gov/pubmed/24753700 http://dx.doi.org/10.3346/jkms.2014.29.4.527 |
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author | Lee, Ki Hong Ahn, Youngkeun Kim, Sung Soo Rhew, Si Hyun Jeong, Young Wook Jang, Soo Young Cho, Jae Yeong Jeong, Hae Chang Park, Keun-Ho Yoon, Nam Sik Sim, Doo Sun Yoon, Hyun Joo Kim, Kye Hun Hong, Young Joon Park, Hyung Wook Kim, Ju Han Cho, Jeong Gwan Park, Jong Chun Jeong, Myung Ho Cho, Myeong-Chan Kim, Chong Jin Kim, Young Jo |
author_facet | Lee, Ki Hong Ahn, Youngkeun Kim, Sung Soo Rhew, Si Hyun Jeong, Young Wook Jang, Soo Young Cho, Jae Yeong Jeong, Hae Chang Park, Keun-Ho Yoon, Nam Sik Sim, Doo Sun Yoon, Hyun Joo Kim, Kye Hun Hong, Young Joon Park, Hyung Wook Kim, Ju Han Cho, Jeong Gwan Park, Jong Chun Jeong, Myung Ho Cho, Myeong-Chan Kim, Chong Jin Kim, Young Jo |
author_sort | Lee, Ki Hong |
collection | PubMed |
description | We compared clinical characteristics, management, and clinical outcomes of nonagenarian acute myocardial infarction (AMI) patients (n=270, 92.3±2.3 yr old) with octogenarian AMI patients (n=2,145, 83.5±2.7 yr old) enrolled in Korean AMI Registry (KAMIR). Nonagenarians were less likely to have hypertension, diabetes and less likely to be prescribed with beta-blockers, statins, and glycoprotein IIb/IIIa inhibitors compared with octogenarians. Although percutaneous coronary intervention (PCI) was preferred in octogenarians than nonagenarians, the success rate of PCI between the two groups was comparable. In-hospital mortality, the composite of in-hospital adverse outcomes and one year mortality were higher in nonagenarians than in octogenarians. However, the composite of the one year major adverse cardiac events (MACEs) was comparable between the two groups without differences in MI or re-PCI rate. PCI improved 1-yr mortality (adjusted hazard ratio [HR], 0.50; 95% confidence interval [CI], 0.36-0.69, P<0.001) and MACEs (adjusted HR, 0.47; 95% CI, 0.37-0.61, P<0.001) without significant complications both in nonagenarians and octogenarians. In conclusion, nonagenarians had similar 1-yr MACEs rates despite of higher in-hospital and 1-yr mortality compared with octogenarian AMI patients. PCI in nonagenarian AMI patients was associated to better 1-yr clinical outcomes. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-3991796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-39917962014-04-21 Characteristics, In-Hospital and Long-Term Clinical Outcomes of Nonagenarian Compared with Octogenarian Acute Myocardial Infarction Patients Lee, Ki Hong Ahn, Youngkeun Kim, Sung Soo Rhew, Si Hyun Jeong, Young Wook Jang, Soo Young Cho, Jae Yeong Jeong, Hae Chang Park, Keun-Ho Yoon, Nam Sik Sim, Doo Sun Yoon, Hyun Joo Kim, Kye Hun Hong, Young Joon Park, Hyung Wook Kim, Ju Han Cho, Jeong Gwan Park, Jong Chun Jeong, Myung Ho Cho, Myeong-Chan Kim, Chong Jin Kim, Young Jo J Korean Med Sci Original Article We compared clinical characteristics, management, and clinical outcomes of nonagenarian acute myocardial infarction (AMI) patients (n=270, 92.3±2.3 yr old) with octogenarian AMI patients (n=2,145, 83.5±2.7 yr old) enrolled in Korean AMI Registry (KAMIR). Nonagenarians were less likely to have hypertension, diabetes and less likely to be prescribed with beta-blockers, statins, and glycoprotein IIb/IIIa inhibitors compared with octogenarians. Although percutaneous coronary intervention (PCI) was preferred in octogenarians than nonagenarians, the success rate of PCI between the two groups was comparable. In-hospital mortality, the composite of in-hospital adverse outcomes and one year mortality were higher in nonagenarians than in octogenarians. However, the composite of the one year major adverse cardiac events (MACEs) was comparable between the two groups without differences in MI or re-PCI rate. PCI improved 1-yr mortality (adjusted hazard ratio [HR], 0.50; 95% confidence interval [CI], 0.36-0.69, P<0.001) and MACEs (adjusted HR, 0.47; 95% CI, 0.37-0.61, P<0.001) without significant complications both in nonagenarians and octogenarians. In conclusion, nonagenarians had similar 1-yr MACEs rates despite of higher in-hospital and 1-yr mortality compared with octogenarian AMI patients. PCI in nonagenarian AMI patients was associated to better 1-yr clinical outcomes. GRAPHICAL ABSTRACT: [Image: see text] The Korean Academy of Medical Sciences 2014-04 2014-04-01 /pmc/articles/PMC3991796/ /pubmed/24753700 http://dx.doi.org/10.3346/jkms.2014.29.4.527 Text en © 2014 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Ki Hong Ahn, Youngkeun Kim, Sung Soo Rhew, Si Hyun Jeong, Young Wook Jang, Soo Young Cho, Jae Yeong Jeong, Hae Chang Park, Keun-Ho Yoon, Nam Sik Sim, Doo Sun Yoon, Hyun Joo Kim, Kye Hun Hong, Young Joon Park, Hyung Wook Kim, Ju Han Cho, Jeong Gwan Park, Jong Chun Jeong, Myung Ho Cho, Myeong-Chan Kim, Chong Jin Kim, Young Jo Characteristics, In-Hospital and Long-Term Clinical Outcomes of Nonagenarian Compared with Octogenarian Acute Myocardial Infarction Patients |
title | Characteristics, In-Hospital and Long-Term Clinical Outcomes of Nonagenarian Compared with Octogenarian Acute Myocardial Infarction Patients |
title_full | Characteristics, In-Hospital and Long-Term Clinical Outcomes of Nonagenarian Compared with Octogenarian Acute Myocardial Infarction Patients |
title_fullStr | Characteristics, In-Hospital and Long-Term Clinical Outcomes of Nonagenarian Compared with Octogenarian Acute Myocardial Infarction Patients |
title_full_unstemmed | Characteristics, In-Hospital and Long-Term Clinical Outcomes of Nonagenarian Compared with Octogenarian Acute Myocardial Infarction Patients |
title_short | Characteristics, In-Hospital and Long-Term Clinical Outcomes of Nonagenarian Compared with Octogenarian Acute Myocardial Infarction Patients |
title_sort | characteristics, in-hospital and long-term clinical outcomes of nonagenarian compared with octogenarian acute myocardial infarction patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991796/ https://www.ncbi.nlm.nih.gov/pubmed/24753700 http://dx.doi.org/10.3346/jkms.2014.29.4.527 |
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