A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

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5′AMP-activated kinase (AMPK) constitutes a hub for cellular metabolic and growth control, thus representing an ideal therapeutic target for prostate cancers (PCas) characterized by increased lipogenesis and activation of mTORC1 pathway. However, whether AMPK activation itself is sufficient to block...

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Detalles Bibliográficos
Autores principales: Zadra, Giorgia, Photopoulos, Cornelia, Tyekucheva, Svitlana, Heidari, Pedram, Weng, Qing Ping, Fedele, Giuseppe, Liu, Hong, Scaglia, Natalia, Priolo, Carmen, Sicinska, Ewa, Mahmood, Umar, Signoretti, Sabina, Birnberg, Neal, Loda, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Backwell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992078/
https://www.ncbi.nlm.nih.gov/pubmed/24497570
http://dx.doi.org/10.1002/emmm.201302734
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