Biscarbamate cross-linked low molecular weight Polyethylenimine polycation as an efficient intra-cellular delivery cargo for cancer therapy

BACKGROUND: A challenge in gene therapy is the efficient delivery of DNA/siRNA to the diseased cells. The physicochemical characteristics of siRNA, such as high molecular weight, negative charges and hydrophilic nature—prevent passive diffusion across the plasma membrane for most cells. A therapeuti...

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Detalles Bibliográficos
Autores principales: Ge, Xuemei, Feng, Jia, Chen, Shun, Zhang, Can, Ouyang, Yuanming, Liu, Zhenguo, Yuan, Weien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992136/
https://www.ncbi.nlm.nih.gov/pubmed/24708586
http://dx.doi.org/10.1186/1477-3155-12-13

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