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Impact of HER2 copy number in IHC2+/FISH-amplified breast cancer on outcome of adjuvant trastuzumab treatment in a large UK cancer network

BACKGROUND: Adjuvant trastuzumab with chemotherapy is standard treatment for HER2-positive breast cancer, defined as either HER2 IHC3+ or IHC2+ and FISH amplified. The aim of this study was to investigate the degree to which HER2 amplification in terms of HER2 gene copy numbers in HER2+IHC2+ cancers...

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Detalles Bibliográficos
Autores principales:	Borley, A, Mercer, T, Morgan, M, Dutton, P, Barrett-Lee, P, Brunelli, M, Jasani, B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Genetics & Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992505/ https://www.ncbi.nlm.nih.gov/pubmed/24691421 http://dx.doi.org/10.1038/bjc.2014.147

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