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IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo

IL-6 plays a pivotal role in favoring T-cell commitment toward a Th17 cell rather than Treg-cell phenotype, as established through in vitro model systems. We predicted that in the absence of IL-6, mice infected with the gastrointestinal helminth Heligmosomoides polygyrus would show reduced Th17-cell...

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Detalles Bibliográficos
Autores principales:	Smith, Katherine A, Maizels, Rick M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Immunity to Infection
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992848/ https://www.ncbi.nlm.nih.gov/pubmed/24185641 http://dx.doi.org/10.1002/eji.201343746

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