Synthesis of a Miniature Lipoarabinomannan

[Image: see text] An analog of Mycobacterium tuberculosis lipoarabinomannan (LAM) has been synthesized containing the characteristic structures of all of its three major components; that is, a mannosylated phosphatidylinositol moiety, an oligomannan, and an oligoarabinan. A highly convergent strateg...

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Detalles Bibliográficos
Autores principales: Gao, Jian, Liao, Guochao, Wang, Lizhen, Guo, Zhongwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992881/
https://www.ncbi.nlm.nih.gov/pubmed/24444032
http://dx.doi.org/10.1021/ol4036903
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author Gao, Jian
Liao, Guochao
Wang, Lizhen
Guo, Zhongwu
author_facet Gao, Jian
Liao, Guochao
Wang, Lizhen
Guo, Zhongwu
author_sort Gao, Jian
collection PubMed
description [Image: see text] An analog of Mycobacterium tuberculosis lipoarabinomannan (LAM) has been synthesized containing the characteristic structures of all of its three major components; that is, a mannosylated phosphatidylinositol moiety, an oligomannan, and an oligoarabinan. A highly convergent strategy was developed that is applicable to the synthesis of other LAM analogs. The synthetic miniature LAM should be useful for various biological studies.
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spelling pubmed-39928812015-01-21 Synthesis of a Miniature Lipoarabinomannan Gao, Jian Liao, Guochao Wang, Lizhen Guo, Zhongwu Org Lett [Image: see text] An analog of Mycobacterium tuberculosis lipoarabinomannan (LAM) has been synthesized containing the characteristic structures of all of its three major components; that is, a mannosylated phosphatidylinositol moiety, an oligomannan, and an oligoarabinan. A highly convergent strategy was developed that is applicable to the synthesis of other LAM analogs. The synthetic miniature LAM should be useful for various biological studies. American Chemical Society 2014-01-21 2014-02-07 /pmc/articles/PMC3992881/ /pubmed/24444032 http://dx.doi.org/10.1021/ol4036903 Text en Copyright © 2014 American Chemical Society
spellingShingle Gao, Jian
Liao, Guochao
Wang, Lizhen
Guo, Zhongwu
Synthesis of a Miniature Lipoarabinomannan
title Synthesis of a Miniature Lipoarabinomannan
title_full Synthesis of a Miniature Lipoarabinomannan
title_fullStr Synthesis of a Miniature Lipoarabinomannan
title_full_unstemmed Synthesis of a Miniature Lipoarabinomannan
title_short Synthesis of a Miniature Lipoarabinomannan
title_sort synthesis of a miniature lipoarabinomannan
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992881/
https://www.ncbi.nlm.nih.gov/pubmed/24444032
http://dx.doi.org/10.1021/ol4036903
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AT wanglizhen synthesisofaminiaturelipoarabinomannan
AT guozhongwu synthesisofaminiaturelipoarabinomannan

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