FOXP2

The forkhead box P2 gene, designated FOXP2, is the first gene implicated in a speech and language disorder. Since its discovery, many studies have been carried out in an attempt to explain the mechanism by which it influences these characteristically human traits. This review presents the story of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Nudel, Ron, Newbury, Dianne F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2013
Materias:
Advanced Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992897/
https://www.ncbi.nlm.nih.gov/pubmed/24765219
http://dx.doi.org/10.1002/wcs.1247
_version_ 1782312609797636096
author Nudel, Ron
Newbury, Dianne F
author_facet Nudel, Ron
Newbury, Dianne F
author_sort Nudel, Ron
collection PubMed
description The forkhead box P2 gene, designated FOXP2, is the first gene implicated in a speech and language disorder. Since its discovery, many studies have been carried out in an attempt to explain the mechanism by which it influences these characteristically human traits. This review presents the story of the discovery of the FOXP2 gene, including early studies of the phenotypic implications of a disruption in the gene. We then discuss recent investigations into the molecular function of the FOXP2 gene, including functional and gene expression studies. We conclude this review by presenting the fascinating results of recent studies of the FOXP2 ortholog in other species that are capable of vocal communication. WIREs Cogn Sci 2013, 4:547–560. doi: 10.1002/wcs.1247
format Online
Article
Text
id pubmed-3992897
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-39928972014-04-22 FOXP2 Nudel, Ron Newbury, Dianne F Wiley Interdiscip Rev Cogn Sci Advanced Review The forkhead box P2 gene, designated FOXP2, is the first gene implicated in a speech and language disorder. Since its discovery, many studies have been carried out in an attempt to explain the mechanism by which it influences these characteristically human traits. This review presents the story of the discovery of the FOXP2 gene, including early studies of the phenotypic implications of a disruption in the gene. We then discuss recent investigations into the molecular function of the FOXP2 gene, including functional and gene expression studies. We conclude this review by presenting the fascinating results of recent studies of the FOXP2 ortholog in other species that are capable of vocal communication. WIREs Cogn Sci 2013, 4:547–560. doi: 10.1002/wcs.1247 John Wiley & Sons, Inc. 2013-09 2013-08-13 /pmc/articles/PMC3992897/ /pubmed/24765219 http://dx.doi.org/10.1002/wcs.1247 Text en © 2013 The Authors. WIREs Cognitive Science published by John Wiley & Sons, Ltd. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Advanced Review
Nudel, Ron
Newbury, Dianne F
FOXP2
title FOXP2
title_full FOXP2
title_fullStr FOXP2
title_full_unstemmed FOXP2
title_short FOXP2
title_sort foxp2
topic Advanced Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992897/
https://www.ncbi.nlm.nih.gov/pubmed/24765219
http://dx.doi.org/10.1002/wcs.1247
work_keys_str_mv AT nudelron foxp2
AT newburydiannef foxp2

Ejemplares similares