Cargando…

Fc gamma Receptor IIa-H131R Polymorphism and Malaria Susceptibility in Sympatric Ethnic Groups, Fulani and Dogon of Mali

It has been previously shown that there are some interethnic differences in susceptibility to malaria between two sympatric ethnic groups of Mali, the Fulani and the Dogon. The lower susceptibility to Plasmodium falciparum malaria seen in the Fulani has not been fully explained by genetic polymorphi...

Descripción completa

Detalles Bibliográficos
Autores principales: Maiga, B, Dolo, A, Touré, O, Dara, V, Tapily, A, Campino, S, Sepulveda, N, Corran, P, Rockett, K, Clark, T G, Troye Blomberg, M, Doumbo, O K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992902/
https://www.ncbi.nlm.nih.gov/pubmed/24117665
http://dx.doi.org/10.1111/sji.12122
_version_ 1782312610923806720
author Maiga, B
Dolo, A
Touré, O
Dara, V
Tapily, A
Campino, S
Sepulveda, N
Corran, P
Rockett, K
Clark, T G
Troye Blomberg, M
Doumbo, O K
author_facet Maiga, B
Dolo, A
Touré, O
Dara, V
Tapily, A
Campino, S
Sepulveda, N
Corran, P
Rockett, K
Clark, T G
Troye Blomberg, M
Doumbo, O K
author_sort Maiga, B
collection PubMed
description It has been previously shown that there are some interethnic differences in susceptibility to malaria between two sympatric ethnic groups of Mali, the Fulani and the Dogon. The lower susceptibility to Plasmodium falciparum malaria seen in the Fulani has not been fully explained by genetic polymorphisms previously known to be associated with malaria resistance, including haemoglobin S (HbS), haemoglobin C (HbC), alpha-thalassaemia and glucose-6-phosphate dehydrogenase (G6PD) deficiency. Given the observed differences in the distribution of FcγRIIa allotypes among different ethnic groups and with malaria susceptibility that have been reported, we analysed the rs1801274-R131H polymorphism in the FcγRIIa gene in a study of Dogon and Fulani in Mali (n = 939). We confirm that the Fulani have less parasite densities, less parasite prevalence, more spleen enlargement and higher levels of total IgG antibodies (anti-CSP, anti-AMA1, anti-MSP1 and anti-MSP2) and more total IgE (P < 0.05) compared with the Dogon ethnic group. Furthermore, the Fulani exhibit higher frequencies of the blood group O (56.5%) compared with the Dogon (43.5%) (P < 0.001). With regard to the FcγRIIa polymorphism and allele frequency, the Fulani group have a higher frequency of the H allele (Fulani 0.474, Dogon 0.341, P < 0.0001), which was associated with greater total IgE production (P = 0.004). Our findings show that the FcγRIIa polymorphism might have an implication in the relative protection seen in the Fulani tribe, with confirmatory studies required in other malaria endemic settings.
format Online
Article
Text
id pubmed-3992902
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher John Wiley & Sons Ltd
record_format MEDLINE/PubMed
spelling pubmed-39929022014-04-22 Fc gamma Receptor IIa-H131R Polymorphism and Malaria Susceptibility in Sympatric Ethnic Groups, Fulani and Dogon of Mali Maiga, B Dolo, A Touré, O Dara, V Tapily, A Campino, S Sepulveda, N Corran, P Rockett, K Clark, T G Troye Blomberg, M Doumbo, O K Scand J Immunol Human Immunology It has been previously shown that there are some interethnic differences in susceptibility to malaria between two sympatric ethnic groups of Mali, the Fulani and the Dogon. The lower susceptibility to Plasmodium falciparum malaria seen in the Fulani has not been fully explained by genetic polymorphisms previously known to be associated with malaria resistance, including haemoglobin S (HbS), haemoglobin C (HbC), alpha-thalassaemia and glucose-6-phosphate dehydrogenase (G6PD) deficiency. Given the observed differences in the distribution of FcγRIIa allotypes among different ethnic groups and with malaria susceptibility that have been reported, we analysed the rs1801274-R131H polymorphism in the FcγRIIa gene in a study of Dogon and Fulani in Mali (n = 939). We confirm that the Fulani have less parasite densities, less parasite prevalence, more spleen enlargement and higher levels of total IgG antibodies (anti-CSP, anti-AMA1, anti-MSP1 and anti-MSP2) and more total IgE (P < 0.05) compared with the Dogon ethnic group. Furthermore, the Fulani exhibit higher frequencies of the blood group O (56.5%) compared with the Dogon (43.5%) (P < 0.001). With regard to the FcγRIIa polymorphism and allele frequency, the Fulani group have a higher frequency of the H allele (Fulani 0.474, Dogon 0.341, P < 0.0001), which was associated with greater total IgE production (P = 0.004). Our findings show that the FcγRIIa polymorphism might have an implication in the relative protection seen in the Fulani tribe, with confirmatory studies required in other malaria endemic settings. John Wiley & Sons Ltd 2014-01 2013-12-19 /pmc/articles/PMC3992902/ /pubmed/24117665 http://dx.doi.org/10.1111/sji.12122 Text en © 2013 The Authors. Scandinavian Journal of Immunology published by John Wiley & Sons Ltd on behalf of Scandanavian Society of Immunology (SSI). http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Human Immunology
Maiga, B
Dolo, A
Touré, O
Dara, V
Tapily, A
Campino, S
Sepulveda, N
Corran, P
Rockett, K
Clark, T G
Troye Blomberg, M
Doumbo, O K
Fc gamma Receptor IIa-H131R Polymorphism and Malaria Susceptibility in Sympatric Ethnic Groups, Fulani and Dogon of Mali
title Fc gamma Receptor IIa-H131R Polymorphism and Malaria Susceptibility in Sympatric Ethnic Groups, Fulani and Dogon of Mali
title_full Fc gamma Receptor IIa-H131R Polymorphism and Malaria Susceptibility in Sympatric Ethnic Groups, Fulani and Dogon of Mali
title_fullStr Fc gamma Receptor IIa-H131R Polymorphism and Malaria Susceptibility in Sympatric Ethnic Groups, Fulani and Dogon of Mali
title_full_unstemmed Fc gamma Receptor IIa-H131R Polymorphism and Malaria Susceptibility in Sympatric Ethnic Groups, Fulani and Dogon of Mali
title_short Fc gamma Receptor IIa-H131R Polymorphism and Malaria Susceptibility in Sympatric Ethnic Groups, Fulani and Dogon of Mali
title_sort fc gamma receptor iia-h131r polymorphism and malaria susceptibility in sympatric ethnic groups, fulani and dogon of mali
topic Human Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992902/
https://www.ncbi.nlm.nih.gov/pubmed/24117665
http://dx.doi.org/10.1111/sji.12122
work_keys_str_mv AT maigab fcgammareceptoriiah131rpolymorphismandmalariasusceptibilityinsympatricethnicgroupsfulanianddogonofmali
AT doloa fcgammareceptoriiah131rpolymorphismandmalariasusceptibilityinsympatricethnicgroupsfulanianddogonofmali
AT toureo fcgammareceptoriiah131rpolymorphismandmalariasusceptibilityinsympatricethnicgroupsfulanianddogonofmali
AT darav fcgammareceptoriiah131rpolymorphismandmalariasusceptibilityinsympatricethnicgroupsfulanianddogonofmali
AT tapilya fcgammareceptoriiah131rpolymorphismandmalariasusceptibilityinsympatricethnicgroupsfulanianddogonofmali
AT campinos fcgammareceptoriiah131rpolymorphismandmalariasusceptibilityinsympatricethnicgroupsfulanianddogonofmali
AT sepulvedan fcgammareceptoriiah131rpolymorphismandmalariasusceptibilityinsympatricethnicgroupsfulanianddogonofmali
AT corranp fcgammareceptoriiah131rpolymorphismandmalariasusceptibilityinsympatricethnicgroupsfulanianddogonofmali
AT rockettk fcgammareceptoriiah131rpolymorphismandmalariasusceptibilityinsympatricethnicgroupsfulanianddogonofmali
AT clarktg fcgammareceptoriiah131rpolymorphismandmalariasusceptibilityinsympatricethnicgroupsfulanianddogonofmali
AT troyeblombergm fcgammareceptoriiah131rpolymorphismandmalariasusceptibilityinsympatricethnicgroupsfulanianddogonofmali
AT doumbook fcgammareceptoriiah131rpolymorphismandmalariasusceptibilityinsympatricethnicgroupsfulanianddogonofmali