A Concise Synthesis of Carolacton

[Image: see text] A synthesis of carolacton, a myxobacterial natural product that has profound effects on Streptococcus mutans biofilms, is reported. The synthesis proceeds via a longest linear sequence of 14 steps from an Evans β-ketoimide and enabled preliminary evaluations of the effects of late-...

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Detalles Bibliográficos
Autores principales: Hallside, Michal S., Brzozowski, Richard S., Wuest, William M., Phillips, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993612/
https://www.ncbi.nlm.nih.gov/pubmed/24483250
http://dx.doi.org/10.1021/ol500004k
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author Hallside, Michal S.
Brzozowski, Richard S.
Wuest, William M.
Phillips, Andrew J.
author_facet Hallside, Michal S.
Brzozowski, Richard S.
Wuest, William M.
Phillips, Andrew J.
author_sort Hallside, Michal S.
collection PubMed
description [Image: see text] A synthesis of carolacton, a myxobacterial natural product that has profound effects on Streptococcus mutans biofilms, is reported. The synthesis proceeds via a longest linear sequence of 14 steps from an Evans β-ketoimide and enabled preliminary evaluations of the effects of late-stage intermediates on S. mutans biofilms. These studies suggest that further investigations into carolacton’s structure–function relationships are warranted.
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spelling pubmed-39936122015-01-31 A Concise Synthesis of Carolacton Hallside, Michal S. Brzozowski, Richard S. Wuest, William M. Phillips, Andrew J. Org Lett [Image: see text] A synthesis of carolacton, a myxobacterial natural product that has profound effects on Streptococcus mutans biofilms, is reported. The synthesis proceeds via a longest linear sequence of 14 steps from an Evans β-ketoimide and enabled preliminary evaluations of the effects of late-stage intermediates on S. mutans biofilms. These studies suggest that further investigations into carolacton’s structure–function relationships are warranted. American Chemical Society 2014-01-31 2014-02-21 /pmc/articles/PMC3993612/ /pubmed/24483250 http://dx.doi.org/10.1021/ol500004k Text en Copyright © 2014 American Chemical Society
spellingShingle Hallside, Michal S.
Brzozowski, Richard S.
Wuest, William M.
Phillips, Andrew J.
A Concise Synthesis of Carolacton
title A Concise Synthesis of Carolacton
title_full A Concise Synthesis of Carolacton
title_fullStr A Concise Synthesis of Carolacton
title_full_unstemmed A Concise Synthesis of Carolacton
title_short A Concise Synthesis of Carolacton
title_sort concise synthesis of carolacton
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993612/
https://www.ncbi.nlm.nih.gov/pubmed/24483250
http://dx.doi.org/10.1021/ol500004k
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