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Rational Domain Swaps Reveal Insights about Chain Length Control by Ketosynthase Domains in Fungal Nonreducing Polyketide Synthases

[Image: see text] A facile genetic methodology in the filamentous fungus Aspergillus nidulans allowed exchange of the starter unit ACP transacylase (SAT) domain in the nonreduced polyketide synthase (NR-PKS) AfoE of the asperfuranone pathway with the SAT domains from 10 other NR-PKSs. The newly crea...

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Detalles Bibliográficos
Autores principales:	Liu, Ting, Sanchez, James F., Chiang, Yi-Ming, Oakley, Berl R., Wang, Clay C. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993715/ https://www.ncbi.nlm.nih.gov/pubmed/24593241 http://dx.doi.org/10.1021/ol5003384

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