Palladium-Catalyzed α-Arylation of Benzylic Phosphonates

[Image: see text] A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)(2)/CataCXium A-based catalyst afforded a reaction between b...

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Detalles Bibliográficos
Autores principales: Montel, Sonia, Raffier, Ludovic, He, Yuying, Walsh, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993846/
https://www.ncbi.nlm.nih.gov/pubmed/24520897
http://dx.doi.org/10.1021/ol5002413
Descripción
Sumario:[Image: see text] A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)(2)/CataCXium A-based catalyst afforded a reaction between benzyl diisopropyl phosphonate derivatives and aryl bromides in good to excellent isolated yields (64–92%).

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