Palladium-Catalyzed α-Arylation of Benzylic Phosphonates

[Image: see text] A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)(2)/CataCXium A-based catalyst afforded a reaction between b...

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Autores principales: Montel, Sonia, Raffier, Ludovic, He, Yuying, Walsh, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993846/
https://www.ncbi.nlm.nih.gov/pubmed/24520897
http://dx.doi.org/10.1021/ol5002413
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author Montel, Sonia
Raffier, Ludovic
He, Yuying
Walsh, Patrick J.
author_facet Montel, Sonia
Raffier, Ludovic
He, Yuying
Walsh, Patrick J.
author_sort Montel, Sonia
collection PubMed
description [Image: see text] A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)(2)/CataCXium A-based catalyst afforded a reaction between benzyl diisopropyl phosphonate derivatives and aryl bromides in good to excellent isolated yields (64–92%).
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spelling pubmed-39938462015-02-12 Palladium-Catalyzed α-Arylation of Benzylic Phosphonates Montel, Sonia Raffier, Ludovic He, Yuying Walsh, Patrick J. Org Lett [Image: see text] A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)(2)/CataCXium A-based catalyst afforded a reaction between benzyl diisopropyl phosphonate derivatives and aryl bromides in good to excellent isolated yields (64–92%). American Chemical Society 2014-02-12 2014-03-07 /pmc/articles/PMC3993846/ /pubmed/24520897 http://dx.doi.org/10.1021/ol5002413 Text en Copyright © 2014 American Chemical Society
spellingShingle Montel, Sonia
Raffier, Ludovic
He, Yuying
Walsh, Patrick J.
Palladium-Catalyzed α-Arylation of Benzylic Phosphonates
title Palladium-Catalyzed α-Arylation of Benzylic Phosphonates
title_full Palladium-Catalyzed α-Arylation of Benzylic Phosphonates
title_fullStr Palladium-Catalyzed α-Arylation of Benzylic Phosphonates
title_full_unstemmed Palladium-Catalyzed α-Arylation of Benzylic Phosphonates
title_short Palladium-Catalyzed α-Arylation of Benzylic Phosphonates
title_sort palladium-catalyzed α-arylation of benzylic phosphonates
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993846/
https://www.ncbi.nlm.nih.gov/pubmed/24520897
http://dx.doi.org/10.1021/ol5002413
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AT raffierludovic palladiumcatalyzedaarylationofbenzylicphosphonates
AT heyuying palladiumcatalyzedaarylationofbenzylicphosphonates
AT walshpatrickj palladiumcatalyzedaarylationofbenzylicphosphonates

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