Iron-Catalyzed Arylation of Heterocycles via Directed C–H Bond Activation

[Image: see text] The iron-catalyzed arylation of aromatic heterocycles, such as pyridines, thiophenes, and furans, has been achieved. The use of an imine directing group allowed for the ortho functionalization of these heterocycles with complete conversion in 15 min at 0 °C. Yields up to 88% were o...

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Autores principales: Sirois, John J., Davis, Riley, DeBoef, Brenton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993849/
https://www.ncbi.nlm.nih.gov/pubmed/24450989
http://dx.doi.org/10.1021/ol403634b
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author Sirois, John J.
Davis, Riley
DeBoef, Brenton
author_facet Sirois, John J.
Davis, Riley
DeBoef, Brenton
author_sort Sirois, John J.
collection PubMed
description [Image: see text] The iron-catalyzed arylation of aromatic heterocycles, such as pyridines, thiophenes, and furans, has been achieved. The use of an imine directing group allowed for the ortho functionalization of these heterocycles with complete conversion in 15 min at 0 °C. Yields up to 88% were observed in the synthesis of 15 heterocyclic biaryls.
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spelling pubmed-39938492015-01-22 Iron-Catalyzed Arylation of Heterocycles via Directed C–H Bond Activation Sirois, John J. Davis, Riley DeBoef, Brenton Org Lett [Image: see text] The iron-catalyzed arylation of aromatic heterocycles, such as pyridines, thiophenes, and furans, has been achieved. The use of an imine directing group allowed for the ortho functionalization of these heterocycles with complete conversion in 15 min at 0 °C. Yields up to 88% were observed in the synthesis of 15 heterocyclic biaryls. American Chemical Society 2014-01-22 2014-02-07 /pmc/articles/PMC3993849/ /pubmed/24450989 http://dx.doi.org/10.1021/ol403634b Text en Copyright © 2014 American Chemical Society
spellingShingle Sirois, John J.
Davis, Riley
DeBoef, Brenton
Iron-Catalyzed Arylation of Heterocycles via Directed C–H Bond Activation
title Iron-Catalyzed Arylation of Heterocycles via Directed C–H Bond Activation
title_full Iron-Catalyzed Arylation of Heterocycles via Directed C–H Bond Activation
title_fullStr Iron-Catalyzed Arylation of Heterocycles via Directed C–H Bond Activation
title_full_unstemmed Iron-Catalyzed Arylation of Heterocycles via Directed C–H Bond Activation
title_short Iron-Catalyzed Arylation of Heterocycles via Directed C–H Bond Activation
title_sort iron-catalyzed arylation of heterocycles via directed c–h bond activation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993849/
https://www.ncbi.nlm.nih.gov/pubmed/24450989
http://dx.doi.org/10.1021/ol403634b
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