Inhibiting Metastatic Breast Cancer Cell Migration via the Synergy of Targeted, pH-triggered siRNA Delivery and Chemokine Axis Blockade

[Image: see text] Because breast cancer patient survival inversely correlates with metastasis, we engineered vehicles to inhibit both the C-X-C chemokine receptor type 4 (CXCR4) and lipocalin-2 (Lcn2) mediated migratory pathways. pH-responsive liposomes were designed to protect and trigger the relea...

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Autores principales: Guo, Peng, You, Jin-Oh, Yang, Jiang, Jia, Di, Moses, Marsha A., Auguste, Debra T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993942/
https://www.ncbi.nlm.nih.gov/pubmed/24467226
http://dx.doi.org/10.1021/mp4004699
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author Guo, Peng
You, Jin-Oh
Yang, Jiang
Jia, Di
Moses, Marsha A.
Auguste, Debra T.
author_facet Guo, Peng
You, Jin-Oh
Yang, Jiang
Jia, Di
Moses, Marsha A.
Auguste, Debra T.
author_sort Guo, Peng
collection PubMed
description [Image: see text] Because breast cancer patient survival inversely correlates with metastasis, we engineered vehicles to inhibit both the C-X-C chemokine receptor type 4 (CXCR4) and lipocalin-2 (Lcn2) mediated migratory pathways. pH-responsive liposomes were designed to protect and trigger the release of Lcn2 siRNA. Liposomes were modified with anti-CXCR4 antibodies to target metastatic breast cancer (MBC) cells and block migration along the CXCR4-CXCL12 axis. This synergistic approach—coupling the CXCR4 axis blockade with Lcn2 silencing—significantly reduced migration in triple-negative human breast cancer cells (88% for MDA-MB-436 and 92% for MDA-MB-231). The results suggested that drug delivery vehicles engineered to attack multiple migratory pathways may effectively slow progression of MBC.
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spelling pubmed-39939422015-01-27 Inhibiting Metastatic Breast Cancer Cell Migration via the Synergy of Targeted, pH-triggered siRNA Delivery and Chemokine Axis Blockade Guo, Peng You, Jin-Oh Yang, Jiang Jia, Di Moses, Marsha A. Auguste, Debra T. Mol Pharm [Image: see text] Because breast cancer patient survival inversely correlates with metastasis, we engineered vehicles to inhibit both the C-X-C chemokine receptor type 4 (CXCR4) and lipocalin-2 (Lcn2) mediated migratory pathways. pH-responsive liposomes were designed to protect and trigger the release of Lcn2 siRNA. Liposomes were modified with anti-CXCR4 antibodies to target metastatic breast cancer (MBC) cells and block migration along the CXCR4-CXCL12 axis. This synergistic approach—coupling the CXCR4 axis blockade with Lcn2 silencing—significantly reduced migration in triple-negative human breast cancer cells (88% for MDA-MB-436 and 92% for MDA-MB-231). The results suggested that drug delivery vehicles engineered to attack multiple migratory pathways may effectively slow progression of MBC. American Chemical Society 2014-01-27 2014-03-03 /pmc/articles/PMC3993942/ /pubmed/24467226 http://dx.doi.org/10.1021/mp4004699 Text en Copyright © 2014 American Chemical Society
spellingShingle Guo, Peng
You, Jin-Oh
Yang, Jiang
Jia, Di
Moses, Marsha A.
Auguste, Debra T.
Inhibiting Metastatic Breast Cancer Cell Migration via the Synergy of Targeted, pH-triggered siRNA Delivery and Chemokine Axis Blockade
title Inhibiting Metastatic Breast Cancer Cell Migration via the Synergy of Targeted, pH-triggered siRNA Delivery and Chemokine Axis Blockade
title_full Inhibiting Metastatic Breast Cancer Cell Migration via the Synergy of Targeted, pH-triggered siRNA Delivery and Chemokine Axis Blockade
title_fullStr Inhibiting Metastatic Breast Cancer Cell Migration via the Synergy of Targeted, pH-triggered siRNA Delivery and Chemokine Axis Blockade
title_full_unstemmed Inhibiting Metastatic Breast Cancer Cell Migration via the Synergy of Targeted, pH-triggered siRNA Delivery and Chemokine Axis Blockade
title_short Inhibiting Metastatic Breast Cancer Cell Migration via the Synergy of Targeted, pH-triggered siRNA Delivery and Chemokine Axis Blockade
title_sort inhibiting metastatic breast cancer cell migration via the synergy of targeted, ph-triggered sirna delivery and chemokine axis blockade
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993942/
https://www.ncbi.nlm.nih.gov/pubmed/24467226
http://dx.doi.org/10.1021/mp4004699
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