Inhibiting Metastatic Breast Cancer Cell Migration via the Synergy of Targeted, pH-triggered siRNA Delivery and Chemokine Axis Blockade

[Image: see text] Because breast cancer patient survival inversely correlates with metastasis, we engineered vehicles to inhibit both the C-X-C chemokine receptor type 4 (CXCR4) and lipocalin-2 (Lcn2) mediated migratory pathways. pH-responsive liposomes were designed to protect and trigger the relea...

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Detalles Bibliográficos
Autores principales: Guo, Peng, You, Jin-Oh, Yang, Jiang, Jia, Di, Moses, Marsha A., Auguste, Debra T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993942/
https://www.ncbi.nlm.nih.gov/pubmed/24467226
http://dx.doi.org/10.1021/mp4004699

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