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Direct Angiotensin AT2 Receptor Stimulation Using a Novel AT2 Receptor Agonist, Compound 21, Evokes Neuroprotection in Conscious Hypertensive Rats

BACKGROUND: In this study, the neuroprotective effect of a novel nonpeptide AT2R agonist, C21, was examined in a conscious model of stroke to verify a class effect of AT2R agonists as neuroprotective agents. METHODS AND RESULTS: Spontaneously hypertensive rats (SHR) were pre-treated for 5 days prior...

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Detalles Bibliográficos
Autores principales:	McCarthy, Claudia A., Vinh, Antony, Miller, Alyson A., Hallberg, Anders, Alterman, Mathias, Callaway, Jennifer K., Widdop, Robert E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994132/ https://www.ncbi.nlm.nih.gov/pubmed/24752645 http://dx.doi.org/10.1371/journal.pone.0095762

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