Antibody Directed against Human YKL-40 Increases Tumor Volume in a Human Melanoma Xenograft Model in Scid Mice

Induced overexpression of the secretory protein YKL-40 promotes tumor growth in xenograft experiments. We investigated if targeting YKL-40 with a monoclonal antibody could inhibit tumor growth. YKL-40 expressing human melanoma cells (LOX) were injected subcutenously in Balb/c scid mice. Animals were...

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Detalles Bibliográficos
Autores principales: Salamon, Johannes, Hoffmann, Tatjana, Elies, Eva, Peldschus, Kersten, Johansen, Julia S., Lüers, Georg, Schumacher, Udo, Wicklein, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994147/
https://www.ncbi.nlm.nih.gov/pubmed/24752554
http://dx.doi.org/10.1371/journal.pone.0095822

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