GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN

Glucose-regulated protein 78 (GRP78), a molecular chaperone widely elevated in human cancers, is critical for endoplasmic reticulum (ER) protein folding, stress signaling and PI3K/AKT activation. Genetic knockout models of GRP78 revealed that GRP78 maintains homeostasis of metabolic organs, includin...

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Detalles Bibliográficos
Autores principales: Chen, Wan-Ting, Zhu, Genyuan, Pfaffenbach, Kyle, Kanel, Gary, Stiles, Bangyan, Lee, Amy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994182/
https://www.ncbi.nlm.nih.gov/pubmed/24141775
http://dx.doi.org/10.1038/onc.2013.437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994182/
https://www.ncbi.nlm.nih.gov/pubmed/24141775
http://dx.doi.org/10.1038/onc.2013.437

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