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GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN

Glucose-regulated protein 78 (GRP78), a molecular chaperone widely elevated in human cancers, is critical for endoplasmic reticulum (ER) protein folding, stress signaling and PI3K/AKT activation. Genetic knockout models of GRP78 revealed that GRP78 maintains homeostasis of metabolic organs, includin...

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Detalles Bibliográficos
Autores principales:	Chen, Wan-Ting, Zhu, Genyuan, Pfaffenbach, Kyle, Kanel, Gary, Stiles, Bangyan, Lee, Amy S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994182/ https://www.ncbi.nlm.nih.gov/pubmed/24141775 http://dx.doi.org/10.1038/onc.2013.437

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