F-box protein complex FBXL19 regulates TGFβ1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation

BACKGROUND: Rac3 is a small GTPase multifunctional protein that regulates cell adhesion, migration, and differentiation. It has been considered as an oncogene in breast cancer; however, its role in esophageal cancer and the regulation of its stability have not been studied. F-box proteins are major...

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Detalles Bibliográficos
Autores principales: Dong, Su, Zhao, Jing, Wei, Jianxin, Bowser, Rachel K, Khoo, Andrew, Liu, Zhonghui, Luketich, James D, Pennathur, Arjun, Ma, Haichun, Zhao, Yutong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994216/
https://www.ncbi.nlm.nih.gov/pubmed/24684802
http://dx.doi.org/10.1186/1476-4598-13-76

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