Discovery of imatinib-responsive FIP1L1-PDGFRA mutation during refractory acute myeloid leukemia transformation of chronic myelomonocytic leukemia

The FIP1L1-PDGFRA rearrangement results in constitutive activation of the tyrosine kinase PDGFRA. Neoplasms harboring this rearrangement are responsive to imatinib mesylate at doses much lower than those recommended for the treatment of chronic myelogenous leukemia. Only a single report has describe...

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Detalles Bibliográficos
Autores principales: Shah, Shilpan, Loghavi, Sanam, Garcia-Manero, Guillermo, Khoury, Joseph D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994268/
https://www.ncbi.nlm.nih.gov/pubmed/24669761
http://dx.doi.org/10.1186/1756-8722-7-26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994268/
https://www.ncbi.nlm.nih.gov/pubmed/24669761
http://dx.doi.org/10.1186/1756-8722-7-26

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