Chemically defined polyethylene glycol siRNA conjugates with enhanced gene silencing effect

The therapeutic application of siRNA suffers from poor bioavailability caused by rapid degradation and elimination. The covalent attachment of PEG is a universal concept to increase molecular size and enhance the pharmacokinetic properties of biomacromolecules. We devised a facile approach for attac...

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Detalles Bibliográficos
Autores principales: Gaziova, Zuzana, Baumann, Volker, Winkler, Anna-Maria, Winkler, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994277/
https://www.ncbi.nlm.nih.gov/pubmed/24613624
http://dx.doi.org/10.1016/j.bmc.2014.02.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994277/
https://www.ncbi.nlm.nih.gov/pubmed/24613624
http://dx.doi.org/10.1016/j.bmc.2014.02.004

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