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Chemically defined polyethylene glycol siRNA conjugates with enhanced gene silencing effect
The therapeutic application of siRNA suffers from poor bioavailability caused by rapid degradation and elimination. The covalent attachment of PEG is a universal concept to increase molecular size and enhance the pharmacokinetic properties of biomacromolecules. We devised a facile approach for attac...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994277/ https://www.ncbi.nlm.nih.gov/pubmed/24613624 http://dx.doi.org/10.1016/j.bmc.2014.02.004 |