CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients

BACKGROUND: GPR40 is a G-protein coupled receptor regulating free fatty acid induced and also glucose induced insulin secretion. We generated neonatally-streptozotocin-treated female rats (n-STZ) and treated them with CNX-011-67, a GPR40 agonist to examine the role of GPR40 in modulation of glucose...

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Detalles Bibliográficos
Autores principales: Sunil, Venkategowda, Verma, Mahesh Kumar, Oommen, Anup M, Sadasivuni, Manojkumar, Singh, Jaideep, Vijayraghav, Dasarahalli N, Chandravanshi, Bhawna, Shetty, Jayalaxmi, Biswas, Sanghamitra, Dandu, Anilkumar, Moolemath, Yoganand, Venkataranganna, Marikunte V, Somesh, Baggavalli P, Jagannath, Madanahalli R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994293/
https://www.ncbi.nlm.nih.gov/pubmed/24666736
http://dx.doi.org/10.1186/2050-6511-15-19

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