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Effects of Acupuncture Stimulation at Different Acupoints on Formalin-Induced Pain in Rats

Acupuncture is the process of stimulating skin regions called meridians or acupoints and has been used to treat pain-related symptoms. However, the pain-relieving effects of acupuncture may be different depending on acupoints. In the present study, the effects of acupuncture on behavioral responses...

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Autores principales: Chang, Kyung Ha, Bai, Sun Joon, Lee, Hyejung, Lee, Bae Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994298/
https://www.ncbi.nlm.nih.gov/pubmed/24757373
http://dx.doi.org/10.4196/kjpp.2014.18.2.121
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author Chang, Kyung Ha
Bai, Sun Joon
Lee, Hyejung
Lee, Bae Hwan
author_facet Chang, Kyung Ha
Bai, Sun Joon
Lee, Hyejung
Lee, Bae Hwan
author_sort Chang, Kyung Ha
collection PubMed
description Acupuncture is the process of stimulating skin regions called meridians or acupoints and has been used to treat pain-related symptoms. However, the pain-relieving effects of acupuncture may be different depending on acupoints. In the present study, the effects of acupuncture on behavioral responses and c-Fos expression were evaluated using a formalin test in male Sprague-Dawley rats in order to clarify the analgesic effects of three different acupoints. Each rat received manual acupuncture at the ST36 (Zusanli), SP9 (Yinlingquan) or BL60 (Kunlun) acupoint before formalin injection. Flinching and licking behaviors were counted by two blinded investigators. Fos-like immunoreactivity was examined by immunohistochemistry in the rat spinal cord. Manual acupuncture treatment at BL60 acupoint showed significant inhibition in flinching behavior but not in licking. Manual acupuncture at ST36 or SP9 tended to inhibit flinching and licking behaviors but the effects were not statistically significant. The acupuncture at ST36, SP9, or BL60 reduced c-Fos expression as compared with the control group. These results suggest that acupuncture especially at the BL60 acupoint is more effective in relieving inflammatory pain than other acupoints.
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spelling pubmed-39942982014-04-22 Effects of Acupuncture Stimulation at Different Acupoints on Formalin-Induced Pain in Rats Chang, Kyung Ha Bai, Sun Joon Lee, Hyejung Lee, Bae Hwan Korean J Physiol Pharmacol Original Article Acupuncture is the process of stimulating skin regions called meridians or acupoints and has been used to treat pain-related symptoms. However, the pain-relieving effects of acupuncture may be different depending on acupoints. In the present study, the effects of acupuncture on behavioral responses and c-Fos expression were evaluated using a formalin test in male Sprague-Dawley rats in order to clarify the analgesic effects of three different acupoints. Each rat received manual acupuncture at the ST36 (Zusanli), SP9 (Yinlingquan) or BL60 (Kunlun) acupoint before formalin injection. Flinching and licking behaviors were counted by two blinded investigators. Fos-like immunoreactivity was examined by immunohistochemistry in the rat spinal cord. Manual acupuncture treatment at BL60 acupoint showed significant inhibition in flinching behavior but not in licking. Manual acupuncture at ST36 or SP9 tended to inhibit flinching and licking behaviors but the effects were not statistically significant. The acupuncture at ST36, SP9, or BL60 reduced c-Fos expression as compared with the control group. These results suggest that acupuncture especially at the BL60 acupoint is more effective in relieving inflammatory pain than other acupoints. The Korean Physiological Society and The Korean Society of Pharmacology 2014-04 2014-04-03 /pmc/articles/PMC3994298/ /pubmed/24757373 http://dx.doi.org/10.4196/kjpp.2014.18.2.121 Text en Copyright © 2014 The Korean Physiological Society and The Korean Society of Pharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chang, Kyung Ha
Bai, Sun Joon
Lee, Hyejung
Lee, Bae Hwan
Effects of Acupuncture Stimulation at Different Acupoints on Formalin-Induced Pain in Rats
title Effects of Acupuncture Stimulation at Different Acupoints on Formalin-Induced Pain in Rats
title_full Effects of Acupuncture Stimulation at Different Acupoints on Formalin-Induced Pain in Rats
title_fullStr Effects of Acupuncture Stimulation at Different Acupoints on Formalin-Induced Pain in Rats
title_full_unstemmed Effects of Acupuncture Stimulation at Different Acupoints on Formalin-Induced Pain in Rats
title_short Effects of Acupuncture Stimulation at Different Acupoints on Formalin-Induced Pain in Rats
title_sort effects of acupuncture stimulation at different acupoints on formalin-induced pain in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994298/
https://www.ncbi.nlm.nih.gov/pubmed/24757373
http://dx.doi.org/10.4196/kjpp.2014.18.2.121
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