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Regular Exercise Training Increases the Number of Endothelial Progenitor Cells and Decreases Homocysteine Levels in Healthy Peripheral Blood

Endothelial progenitor cells (EPCs) are known to play an important role in the repair of damaged blood vessels. We used an endothelial progenitor cell colony-forming assay (EPC-CFA) to determine whether EPC numbers could be increased in healthy individuals through regular exercise training. The numb...

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Autores principales: Choi, Jeong Kyu, Moon, Ki Myung, Jung, Seok Yun, Kim, Ji Yong, Choi, Sung Hyun, Kim, Da Yeon, Kang, Songhwa, Chu, Chong Woo, Kwon, Sang Mo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994304/
https://www.ncbi.nlm.nih.gov/pubmed/24757379
http://dx.doi.org/10.4196/kjpp.2014.18.2.163
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author Choi, Jeong Kyu
Moon, Ki Myung
Jung, Seok Yun
Kim, Ji Yong
Choi, Sung Hyun
Kim, Da Yeon
Kang, Songhwa
Chu, Chong Woo
Kwon, Sang Mo
author_facet Choi, Jeong Kyu
Moon, Ki Myung
Jung, Seok Yun
Kim, Ji Yong
Choi, Sung Hyun
Kim, Da Yeon
Kang, Songhwa
Chu, Chong Woo
Kwon, Sang Mo
author_sort Choi, Jeong Kyu
collection PubMed
description Endothelial progenitor cells (EPCs) are known to play an important role in the repair of damaged blood vessels. We used an endothelial progenitor cell colony-forming assay (EPC-CFA) to determine whether EPC numbers could be increased in healthy individuals through regular exercise training. The number of functional EPCs obtained from human peripheral blood-derived AC133 stem cells was measured after a 28-day regular exercise training program. The number of total endothelial progenitor cell colony-forming units (EPC-CFU) was significantly increased compared to that in the control group (p=0.02, n=5). In addition, we observed a significant decrease in homocysteine levels followed by an increase in the number of EPC-CFUs (p=0.04, n=5), indicating that the 28-day regular exercise training could increase the number of EPC colonies and decrease homocysteine levels. Moreover, an inverse correlation was observed between small-endothelial progenitor cell colony-forming units (small-EPC-CFUs) and plasma homocysteine levels in healthy men (r=-0.8125, p=0.047). We found that regular exercise training could increase the number of EPC-CFUs and decrease homocysteine levels, thus decreasing the cardiovascular disease risk in men.
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spelling pubmed-39943042014-04-22 Regular Exercise Training Increases the Number of Endothelial Progenitor Cells and Decreases Homocysteine Levels in Healthy Peripheral Blood Choi, Jeong Kyu Moon, Ki Myung Jung, Seok Yun Kim, Ji Yong Choi, Sung Hyun Kim, Da Yeon Kang, Songhwa Chu, Chong Woo Kwon, Sang Mo Korean J Physiol Pharmacol Original Article Endothelial progenitor cells (EPCs) are known to play an important role in the repair of damaged blood vessels. We used an endothelial progenitor cell colony-forming assay (EPC-CFA) to determine whether EPC numbers could be increased in healthy individuals through regular exercise training. The number of functional EPCs obtained from human peripheral blood-derived AC133 stem cells was measured after a 28-day regular exercise training program. The number of total endothelial progenitor cell colony-forming units (EPC-CFU) was significantly increased compared to that in the control group (p=0.02, n=5). In addition, we observed a significant decrease in homocysteine levels followed by an increase in the number of EPC-CFUs (p=0.04, n=5), indicating that the 28-day regular exercise training could increase the number of EPC colonies and decrease homocysteine levels. Moreover, an inverse correlation was observed between small-endothelial progenitor cell colony-forming units (small-EPC-CFUs) and plasma homocysteine levels in healthy men (r=-0.8125, p=0.047). We found that regular exercise training could increase the number of EPC-CFUs and decrease homocysteine levels, thus decreasing the cardiovascular disease risk in men. The Korean Physiological Society and The Korean Society of Pharmacology 2014-04 2014-04-03 /pmc/articles/PMC3994304/ /pubmed/24757379 http://dx.doi.org/10.4196/kjpp.2014.18.2.163 Text en Copyright © 2014 The Korean Physiological Society and The Korean Society of Pharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Choi, Jeong Kyu
Moon, Ki Myung
Jung, Seok Yun
Kim, Ji Yong
Choi, Sung Hyun
Kim, Da Yeon
Kang, Songhwa
Chu, Chong Woo
Kwon, Sang Mo
Regular Exercise Training Increases the Number of Endothelial Progenitor Cells and Decreases Homocysteine Levels in Healthy Peripheral Blood
title Regular Exercise Training Increases the Number of Endothelial Progenitor Cells and Decreases Homocysteine Levels in Healthy Peripheral Blood
title_full Regular Exercise Training Increases the Number of Endothelial Progenitor Cells and Decreases Homocysteine Levels in Healthy Peripheral Blood
title_fullStr Regular Exercise Training Increases the Number of Endothelial Progenitor Cells and Decreases Homocysteine Levels in Healthy Peripheral Blood
title_full_unstemmed Regular Exercise Training Increases the Number of Endothelial Progenitor Cells and Decreases Homocysteine Levels in Healthy Peripheral Blood
title_short Regular Exercise Training Increases the Number of Endothelial Progenitor Cells and Decreases Homocysteine Levels in Healthy Peripheral Blood
title_sort regular exercise training increases the number of endothelial progenitor cells and decreases homocysteine levels in healthy peripheral blood
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994304/
https://www.ncbi.nlm.nih.gov/pubmed/24757379
http://dx.doi.org/10.4196/kjpp.2014.18.2.163
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