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Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction

This study was to determine the correlation between endothelial function and neuro-endocrine-immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction models were established in male Wistar rats after exposure...

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Detalles Bibliográficos
Autores principales: Li, Lujin, Jia, Zhenghua, Xu, Ling, Wu, Yiling, Zheng, Qingshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994306/
https://www.ncbi.nlm.nih.gov/pubmed/24757381
http://dx.doi.org/10.4196/kjpp.2014.18.2.177
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author Li, Lujin
Jia, Zhenghua
Xu, Ling
Wu, Yiling
Zheng, Qingshan
author_facet Li, Lujin
Jia, Zhenghua
Xu, Ling
Wu, Yiling
Zheng, Qingshan
author_sort Li, Lujin
collection PubMed
description This study was to determine the correlation between endothelial function and neuro-endocrine-immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction models were established in male Wistar rats after exposure to homocysteine (Hcy), high fat diet (HFD) and Hcy+HFD. The results showed that there was endothelial dysfunction in all three models with varying degrees. However, the expression of NEI network was totally different. Interestingly, treatment with simvastatin was able to improve vascular endothelial function and restored the imbalance of the NEI network, observed in the Hcy+HFD group. The results indicated that NEI network may have a strong association with endothelial function, and this relationship can be used to distinguish different risk factors and evaluate drug effects.
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spelling pubmed-39943062014-04-22 Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction Li, Lujin Jia, Zhenghua Xu, Ling Wu, Yiling Zheng, Qingshan Korean J Physiol Pharmacol Original Article This study was to determine the correlation between endothelial function and neuro-endocrine-immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction models were established in male Wistar rats after exposure to homocysteine (Hcy), high fat diet (HFD) and Hcy+HFD. The results showed that there was endothelial dysfunction in all three models with varying degrees. However, the expression of NEI network was totally different. Interestingly, treatment with simvastatin was able to improve vascular endothelial function and restored the imbalance of the NEI network, observed in the Hcy+HFD group. The results indicated that NEI network may have a strong association with endothelial function, and this relationship can be used to distinguish different risk factors and evaluate drug effects. The Korean Physiological Society and The Korean Society of Pharmacology 2014-04 2014-04-03 /pmc/articles/PMC3994306/ /pubmed/24757381 http://dx.doi.org/10.4196/kjpp.2014.18.2.177 Text en Copyright © 2014 The Korean Physiological Society and The Korean Society of Pharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Li, Lujin
Jia, Zhenghua
Xu, Ling
Wu, Yiling
Zheng, Qingshan
Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction
title Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction
title_full Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction
title_fullStr Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction
title_full_unstemmed Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction
title_short Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction
title_sort expression profile of neuro-endocrine-immune network in rats with vascular endothelial dysfunction
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994306/
https://www.ncbi.nlm.nih.gov/pubmed/24757381
http://dx.doi.org/10.4196/kjpp.2014.18.2.177
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