GE23077 binds to the RNA polymerase ‘i’ and ‘i+1’ sites and prevents the binding of initiating nucleotides

Using a combination of genetic, biochemical, and structural approaches, we show that the cyclic-peptide antibiotic GE23077 (GE) binds directly to the bacterial RNA polymerase (RNAP) active-center ‘i’ and ‘i+1’ nucleotide binding sites, preventing the binding of initiating nucleotides, and thereby pr...

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Detalles Bibliográficos
Autores principales: Zhang, Yu, Degen, David, Ho, Mary X, Sineva, Elena, Ebright, Katherine Y, Ebright, Yon W, Mekler, Vladimir, Vahedian-Movahed, Hanif, Feng, Yu, Yin, Ruiheng, Tuske, Steve, Irschik, Herbert, Jansen, Rolf, Maffioli, Sonia, Donadio, Stefano, Arnold, Eddy, Ebright, Richard H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994528/
https://www.ncbi.nlm.nih.gov/pubmed/24755292
http://dx.doi.org/10.7554/eLife.02450

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