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Assessment of stress & related albuminuria in caregivers of severe mentally ill persons

BACKGROUND & OBJECTIVES: The family caregivers of patients with chronic diseases are known to undergo psychiatric stress leading to oxidative damage to glomerular membrane of kidney resulting in proteinuria. This study was aimed to compare current anxiety, depression levels and urinary albumin:c...

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Autores principales: Dalui, Anirban, Guha, Prathama, De, Angshuman, Chakraborty, Sandip, Chakraborty, Indranil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994734/
https://www.ncbi.nlm.nih.gov/pubmed/24604053
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author Dalui, Anirban
Guha, Prathama
De, Angshuman
Chakraborty, Sandip
Chakraborty, Indranil
author_facet Dalui, Anirban
Guha, Prathama
De, Angshuman
Chakraborty, Sandip
Chakraborty, Indranil
author_sort Dalui, Anirban
collection PubMed
description BACKGROUND & OBJECTIVES: The family caregivers of patients with chronic diseases are known to undergo psychiatric stress leading to oxidative damage to glomerular membrane of kidney resulting in proteinuria. This study was aimed to compare current anxiety, depression levels and urinary albumin:creatinine ratio between primary caregivers of chronic mental patients and matched controls, and also whether the urinary albumin : creatinine ratio is correlated with stress factors (state and trait anxiety level, depression and caregiver burden) amongst caregivers. METHODS: The present cross-sectional study included 131 subjects (93 primary caregivers of patients with major mental illness as cases and 38 normal controls). They completed the Burden Assessment Schedule of SCARF, State Trait Anxiety Inventory and Beck's Depression Inventory. A spot urine sample was tested for urinary albumin : creatinine ratio from all study subjects. RESULTS: Mean values of current State and Trait anxiety, depression, urinary albumin:creatinine ratio were significantly higher in caregivers than controls (P < 0.001). Urinary albumin : creatinine ratio was significantly correlated (P < 0.001) with State and Trait anxiety level, depression as well as caregiver burden. INTERPRETATION & CONCLUSIONS: The study demonstrated depression, anxiety and albuminuria amongst primary caregivers of patients with mental illness. Increase in the caregivers’ burden, depression and anxiety resulted in an increase in the urinary albumin: creatinine ratio. This indicates that psychological stress is one of the determinants of albumin excretion rate in otherwise healthy subjects.
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spelling pubmed-39947342014-04-23 Assessment of stress & related albuminuria in caregivers of severe mentally ill persons Dalui, Anirban Guha, Prathama De, Angshuman Chakraborty, Sandip Chakraborty, Indranil Indian J Med Res Student IJMR BACKGROUND & OBJECTIVES: The family caregivers of patients with chronic diseases are known to undergo psychiatric stress leading to oxidative damage to glomerular membrane of kidney resulting in proteinuria. This study was aimed to compare current anxiety, depression levels and urinary albumin:creatinine ratio between primary caregivers of chronic mental patients and matched controls, and also whether the urinary albumin : creatinine ratio is correlated with stress factors (state and trait anxiety level, depression and caregiver burden) amongst caregivers. METHODS: The present cross-sectional study included 131 subjects (93 primary caregivers of patients with major mental illness as cases and 38 normal controls). They completed the Burden Assessment Schedule of SCARF, State Trait Anxiety Inventory and Beck's Depression Inventory. A spot urine sample was tested for urinary albumin : creatinine ratio from all study subjects. RESULTS: Mean values of current State and Trait anxiety, depression, urinary albumin:creatinine ratio were significantly higher in caregivers than controls (P < 0.001). Urinary albumin : creatinine ratio was significantly correlated (P < 0.001) with State and Trait anxiety level, depression as well as caregiver burden. INTERPRETATION & CONCLUSIONS: The study demonstrated depression, anxiety and albuminuria amongst primary caregivers of patients with mental illness. Increase in the caregivers’ burden, depression and anxiety resulted in an increase in the urinary albumin: creatinine ratio. This indicates that psychological stress is one of the determinants of albumin excretion rate in otherwise healthy subjects. Medknow Publications & Media Pvt Ltd 2014-01 /pmc/articles/PMC3994734/ /pubmed/24604053 Text en Copyright: © Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Student IJMR
Dalui, Anirban
Guha, Prathama
De, Angshuman
Chakraborty, Sandip
Chakraborty, Indranil
Assessment of stress & related albuminuria in caregivers of severe mentally ill persons
title Assessment of stress & related albuminuria in caregivers of severe mentally ill persons
title_full Assessment of stress & related albuminuria in caregivers of severe mentally ill persons
title_fullStr Assessment of stress & related albuminuria in caregivers of severe mentally ill persons
title_full_unstemmed Assessment of stress & related albuminuria in caregivers of severe mentally ill persons
title_short Assessment of stress & related albuminuria in caregivers of severe mentally ill persons
title_sort assessment of stress & related albuminuria in caregivers of severe mentally ill persons
topic Student IJMR
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994734/
https://www.ncbi.nlm.nih.gov/pubmed/24604053
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