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Decreasing Cx36 Gap Junction Coupling Compensates for Overactive K(ATP) Channels to Restore Insulin Secretion and Prevent Hyperglycemia in a Mouse Model of Neonatal Diabetes

Mutations to the ATP-sensitive K(+) channel (K(ATP) channel) that reduce the sensitivity of ATP inhibition cause neonatal diabetes mellitus via suppression of β-cell glucose-stimulated free calcium activity ([Ca(2+)](i)) and insulin secretion. Connexin-36 (Cx36) gap junctions also regulate islet ele...

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Detalles Bibliográficos
Autores principales:	Nguyen, Linda M., Pozzoli, Marina, Hraha, Thomas H., Benninger, Richard K.P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994954/ https://www.ncbi.nlm.nih.gov/pubmed/24458355 http://dx.doi.org/10.2337/db13-1048

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