MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer

MicroRNA deregulation is frequent in human colorectal cancers (CRCs), but little is known as to whether it represents a bystander event or actually drives tumor progression in vivo. We show that miR-135b overexpression is triggered in mice and humans by APC loss, PTEN/PI3K pathway deregulation, and...

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Detalles Bibliográficos
Autores principales: Valeri, Nicola, Braconi, Chiara, Gasparini, Pierluigi, Murgia, Claudio, Lampis, Andrea, Paulus-Hock, Viola, Hart, Jonathan R., Ueno, Lynn, Grivennikov, Sergei I., Lovat, Francesca, Paone, Alessio, Cascione, Luciano, Sumani, Khlea M., Veronese, Angelo, Fabbri, Muller, Carasi, Stefania, Alder, Hansjuerg, Lanza, Giovanni, Gafa’, Roberta, Moyer, Mary P., Ridgway, Rachel A., Cordero, Julia, Nuovo, Gerard J., Frankel, Wendy L., Rugge, Massimo, Fassan, Matteo, Groden, Joanna, Vogt, Peter K., Karin, Michael, Sansom, Owen J., Croce, Carlo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995091/
https://www.ncbi.nlm.nih.gov/pubmed/24735923
http://dx.doi.org/10.1016/j.ccr.2014.03.006

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