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Impact of completeness of revascularization by coronary intervention on exercise capacity early after acute ST-elevation myocardial infarction

BACKGROUND: The importance of achieving complete revascularization by percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (MI) on exercise capacity remains unclear. OBJECTIVE: To compare exercise capacity early after acute ST-elevation myocardial infarction (STEMI),...

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Autores principales: Zhao, Wei, Bai, Jin, Zhang, Fuchun, Guo, Lijun, Gao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995092/
https://www.ncbi.nlm.nih.gov/pubmed/24641986
http://dx.doi.org/10.1186/1749-8090-9-50
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author Zhao, Wei
Bai, Jin
Zhang, Fuchun
Guo, Lijun
Gao, Wei
author_facet Zhao, Wei
Bai, Jin
Zhang, Fuchun
Guo, Lijun
Gao, Wei
author_sort Zhao, Wei
collection PubMed
description BACKGROUND: The importance of achieving complete revascularization by percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (MI) on exercise capacity remains unclear. OBJECTIVE: To compare exercise capacity early after acute ST-elevation myocardial infarction (STEMI), in patients receiving PCI with stenting, between those completely revascularized (CR) and those incompletely revascularized (IR). METHODS: We retrospectively reviewed 326 patients [single-vessel disease (SVD) group, 118 patients; multivessel disease (MVD) with CR group, 112 patients; MVD with IR group, 96 patients] who underwent cardiopulmonary exercise testing 7–30 days after STEMI to measure peak oxygen uptake (VO(2peak)), oxygen uptake at anaerobic threshold (VO(2AT)), and peak oxygen pulse. Demographic data, presence of concomitant diseases, STEMI characteristics, and echocardiography and angiography findings were evaluated. RESULTS: Most patients were male (89.0%) and mean age was 55.6 ± 11.2 years. Ischemic ST deviation occurred in 7.1%, with no significant difference between groups. VO(2peak) and VO(2AT) did not differ significantly between groups, despite a trend to be lower in the CR and IR groups compared with the SVD group. Peak oxygen pulse was significantly higher in the SVD group than in the IR group (p = 0.005). After adjustment for age, gender, body mass index, cardiovascular risk factors, MI characteristics and echocardiography parameters, CR was not an independent predictor of VO(2peak) (OR = −0.123, 95% confidence interval [CI] -2.986 to 0.232, p = 0.093), VO(2AT) (OR = 0.002, 95% CI 1.735 to 1.773, p = 0.983), or peak oxygen pulse (OR = −0.102, 95% CI −1.435 to 0.105, p = 0.090). CONCLUSION: CR in patients with STEMI treated with PCI for multivessel disease might show no benefit on short-term exercise tolerance over IR.
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spelling pubmed-39950922014-04-23 Impact of completeness of revascularization by coronary intervention on exercise capacity early after acute ST-elevation myocardial infarction Zhao, Wei Bai, Jin Zhang, Fuchun Guo, Lijun Gao, Wei J Cardiothorac Surg Research Article BACKGROUND: The importance of achieving complete revascularization by percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (MI) on exercise capacity remains unclear. OBJECTIVE: To compare exercise capacity early after acute ST-elevation myocardial infarction (STEMI), in patients receiving PCI with stenting, between those completely revascularized (CR) and those incompletely revascularized (IR). METHODS: We retrospectively reviewed 326 patients [single-vessel disease (SVD) group, 118 patients; multivessel disease (MVD) with CR group, 112 patients; MVD with IR group, 96 patients] who underwent cardiopulmonary exercise testing 7–30 days after STEMI to measure peak oxygen uptake (VO(2peak)), oxygen uptake at anaerobic threshold (VO(2AT)), and peak oxygen pulse. Demographic data, presence of concomitant diseases, STEMI characteristics, and echocardiography and angiography findings were evaluated. RESULTS: Most patients were male (89.0%) and mean age was 55.6 ± 11.2 years. Ischemic ST deviation occurred in 7.1%, with no significant difference between groups. VO(2peak) and VO(2AT) did not differ significantly between groups, despite a trend to be lower in the CR and IR groups compared with the SVD group. Peak oxygen pulse was significantly higher in the SVD group than in the IR group (p = 0.005). After adjustment for age, gender, body mass index, cardiovascular risk factors, MI characteristics and echocardiography parameters, CR was not an independent predictor of VO(2peak) (OR = −0.123, 95% confidence interval [CI] -2.986 to 0.232, p = 0.093), VO(2AT) (OR = 0.002, 95% CI 1.735 to 1.773, p = 0.983), or peak oxygen pulse (OR = −0.102, 95% CI −1.435 to 0.105, p = 0.090). CONCLUSION: CR in patients with STEMI treated with PCI for multivessel disease might show no benefit on short-term exercise tolerance over IR. BioMed Central 2014-03-19 /pmc/articles/PMC3995092/ /pubmed/24641986 http://dx.doi.org/10.1186/1749-8090-9-50 Text en Copyright © 2014 Zhao et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Zhao, Wei
Bai, Jin
Zhang, Fuchun
Guo, Lijun
Gao, Wei
Impact of completeness of revascularization by coronary intervention on exercise capacity early after acute ST-elevation myocardial infarction
title Impact of completeness of revascularization by coronary intervention on exercise capacity early after acute ST-elevation myocardial infarction
title_full Impact of completeness of revascularization by coronary intervention on exercise capacity early after acute ST-elevation myocardial infarction
title_fullStr Impact of completeness of revascularization by coronary intervention on exercise capacity early after acute ST-elevation myocardial infarction
title_full_unstemmed Impact of completeness of revascularization by coronary intervention on exercise capacity early after acute ST-elevation myocardial infarction
title_short Impact of completeness of revascularization by coronary intervention on exercise capacity early after acute ST-elevation myocardial infarction
title_sort impact of completeness of revascularization by coronary intervention on exercise capacity early after acute st-elevation myocardial infarction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995092/
https://www.ncbi.nlm.nih.gov/pubmed/24641986
http://dx.doi.org/10.1186/1749-8090-9-50
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