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Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans
Objective: Clinical follow-up of implant survival in 11 patients comparing two different methods for mesenchymal stem cell (MSC) isolation (Ficoll and bone marrow aspirate concentrate [BMAC]) applied in maxillary sinus augmentation. Methods: Mononuclear cells, including MSCs, were concentrated with...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995205/ https://www.ncbi.nlm.nih.gov/pubmed/24804168 http://dx.doi.org/10.1089/biores.2014.0003 |
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author | Duttenhoefer, Fabian Hieber, Stefan F. Stricker, Andres Schmelzeisen, Rainer Gutwald, Ralf Sauerbier, Sebastian |
author_facet | Duttenhoefer, Fabian Hieber, Stefan F. Stricker, Andres Schmelzeisen, Rainer Gutwald, Ralf Sauerbier, Sebastian |
author_sort | Duttenhoefer, Fabian |
collection | PubMed |
description | Objective: Clinical follow-up of implant survival in 11 patients comparing two different methods for mesenchymal stem cell (MSC) isolation (Ficoll and bone marrow aspirate concentrate [BMAC]) applied in maxillary sinus augmentation. Methods: Mononuclear cells, including MSCs, were concentrated with either Ficoll (control group, n=6 sinus) or BMAC (test group, n=12 sinus) and transplanted in combination with bovine bone mineral. A total of 50 implants were placed in a second surgical intervention (17 Ficoll/33 BMAC) and loaded after 4 months. Overall implant survival was assessed with a Kaplan-Meier model using package survival under R. Results: Implant survival of the Ficoll group was 100% compared with the BMAC group, which had 93.4% survival (95% confidence interval, 0.849–1). The difference between the groups was not significant (p=0.381). Conclusion: The BMAC system is an effective and suitable “chair-side” method for clinical application in hard tissue regeneration. |
format | Online Article Text |
id | pubmed-3995205 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Mary Ann Liebert, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-39952052014-05-06 Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans Duttenhoefer, Fabian Hieber, Stefan F. Stricker, Andres Schmelzeisen, Rainer Gutwald, Ralf Sauerbier, Sebastian Biores Open Access Technical Report Objective: Clinical follow-up of implant survival in 11 patients comparing two different methods for mesenchymal stem cell (MSC) isolation (Ficoll and bone marrow aspirate concentrate [BMAC]) applied in maxillary sinus augmentation. Methods: Mononuclear cells, including MSCs, were concentrated with either Ficoll (control group, n=6 sinus) or BMAC (test group, n=12 sinus) and transplanted in combination with bovine bone mineral. A total of 50 implants were placed in a second surgical intervention (17 Ficoll/33 BMAC) and loaded after 4 months. Overall implant survival was assessed with a Kaplan-Meier model using package survival under R. Results: Implant survival of the Ficoll group was 100% compared with the BMAC group, which had 93.4% survival (95% confidence interval, 0.849–1). The difference between the groups was not significant (p=0.381). Conclusion: The BMAC system is an effective and suitable “chair-side” method for clinical application in hard tissue regeneration. Mary Ann Liebert, Inc. 2014-04-01 /pmc/articles/PMC3995205/ /pubmed/24804168 http://dx.doi.org/10.1089/biores.2014.0003 Text en Copyright 2014, Mary Ann Liebert, Inc. |
spellingShingle | Technical Report Duttenhoefer, Fabian Hieber, Stefan F. Stricker, Andres Schmelzeisen, Rainer Gutwald, Ralf Sauerbier, Sebastian Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans |
title | Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans |
title_full | Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans |
title_fullStr | Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans |
title_full_unstemmed | Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans |
title_short | Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans |
title_sort | follow-up of implant survival comparing ficoll and bone marrow aspirate concentrate methods for hard tissue regeneration with mesenchymal stem cells in humans |
topic | Technical Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995205/ https://www.ncbi.nlm.nih.gov/pubmed/24804168 http://dx.doi.org/10.1089/biores.2014.0003 |
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