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Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans

Objective: Clinical follow-up of implant survival in 11 patients comparing two different methods for mesenchymal stem cell (MSC) isolation (Ficoll and bone marrow aspirate concentrate [BMAC]) applied in maxillary sinus augmentation. Methods: Mononuclear cells, including MSCs, were concentrated with...

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Autores principales: Duttenhoefer, Fabian, Hieber, Stefan F., Stricker, Andres, Schmelzeisen, Rainer, Gutwald, Ralf, Sauerbier, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995205/
https://www.ncbi.nlm.nih.gov/pubmed/24804168
http://dx.doi.org/10.1089/biores.2014.0003
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author Duttenhoefer, Fabian
Hieber, Stefan F.
Stricker, Andres
Schmelzeisen, Rainer
Gutwald, Ralf
Sauerbier, Sebastian
author_facet Duttenhoefer, Fabian
Hieber, Stefan F.
Stricker, Andres
Schmelzeisen, Rainer
Gutwald, Ralf
Sauerbier, Sebastian
author_sort Duttenhoefer, Fabian
collection PubMed
description Objective: Clinical follow-up of implant survival in 11 patients comparing two different methods for mesenchymal stem cell (MSC) isolation (Ficoll and bone marrow aspirate concentrate [BMAC]) applied in maxillary sinus augmentation. Methods: Mononuclear cells, including MSCs, were concentrated with either Ficoll (control group, n=6 sinus) or BMAC (test group, n=12 sinus) and transplanted in combination with bovine bone mineral. A total of 50 implants were placed in a second surgical intervention (17 Ficoll/33 BMAC) and loaded after 4 months. Overall implant survival was assessed with a Kaplan-Meier model using package survival under R. Results: Implant survival of the Ficoll group was 100% compared with the BMAC group, which had 93.4% survival (95% confidence interval, 0.849–1). The difference between the groups was not significant (p=0.381). Conclusion: The BMAC system is an effective and suitable “chair-side” method for clinical application in hard tissue regeneration.
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spelling pubmed-39952052014-05-06 Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans Duttenhoefer, Fabian Hieber, Stefan F. Stricker, Andres Schmelzeisen, Rainer Gutwald, Ralf Sauerbier, Sebastian Biores Open Access Technical Report Objective: Clinical follow-up of implant survival in 11 patients comparing two different methods for mesenchymal stem cell (MSC) isolation (Ficoll and bone marrow aspirate concentrate [BMAC]) applied in maxillary sinus augmentation. Methods: Mononuclear cells, including MSCs, were concentrated with either Ficoll (control group, n=6 sinus) or BMAC (test group, n=12 sinus) and transplanted in combination with bovine bone mineral. A total of 50 implants were placed in a second surgical intervention (17 Ficoll/33 BMAC) and loaded after 4 months. Overall implant survival was assessed with a Kaplan-Meier model using package survival under R. Results: Implant survival of the Ficoll group was 100% compared with the BMAC group, which had 93.4% survival (95% confidence interval, 0.849–1). The difference between the groups was not significant (p=0.381). Conclusion: The BMAC system is an effective and suitable “chair-side” method for clinical application in hard tissue regeneration. Mary Ann Liebert, Inc. 2014-04-01 /pmc/articles/PMC3995205/ /pubmed/24804168 http://dx.doi.org/10.1089/biores.2014.0003 Text en Copyright 2014, Mary Ann Liebert, Inc.
spellingShingle Technical Report
Duttenhoefer, Fabian
Hieber, Stefan F.
Stricker, Andres
Schmelzeisen, Rainer
Gutwald, Ralf
Sauerbier, Sebastian
Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans
title Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans
title_full Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans
title_fullStr Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans
title_full_unstemmed Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans
title_short Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans
title_sort follow-up of implant survival comparing ficoll and bone marrow aspirate concentrate methods for hard tissue regeneration with mesenchymal stem cells in humans
topic Technical Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995205/
https://www.ncbi.nlm.nih.gov/pubmed/24804168
http://dx.doi.org/10.1089/biores.2014.0003
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