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Behavioural Outcome in Children with Congenital Adrenal Hyperplasia: Experience of a Single Centre

The aim of this study was to determine the behavioral outcome in children with CAH and to identify the risk factors that may influence it. Participants (aged 6–18 years) included 29 girls and 20 boys with CAH and unaffected siblings (25 girls and 17 boys). Psychological adjustment was assessed with...

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Autores principales: Idris, Arini Nuran, Chandran, Viji, Syed Zakaria, Syed Zulkifli, Rasat, Rahmah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995314/
https://www.ncbi.nlm.nih.gov/pubmed/24799898
http://dx.doi.org/10.1155/2014/483718
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author Idris, Arini Nuran
Chandran, Viji
Syed Zakaria, Syed Zulkifli
Rasat, Rahmah
author_facet Idris, Arini Nuran
Chandran, Viji
Syed Zakaria, Syed Zulkifli
Rasat, Rahmah
author_sort Idris, Arini Nuran
collection PubMed
description The aim of this study was to determine the behavioral outcome in children with CAH and to identify the risk factors that may influence it. Participants (aged 6–18 years) included 29 girls and 20 boys with CAH and unaffected siblings (25 girls and 17 boys). Psychological adjustment was assessed with parent reports on the Child Behavior Checklist (CBCL). Information about disease characteristics was obtained from medical records. Our study reveals that there was higher incidence of parent-reported problem of anxious/depressed and withdrawn/depressed behaviours, somatic complaints, social, thought, and attention problems, and rule-breaking, aggressive, internalizing, and externalizing behaviour among children with CAH compared to controls. The prevalence of internalizing behaviour problems was higher in CAH boys compared with that of controls. Psychosocial adjustment of girls with CAH was found to be similar to unaffected female controls and was within the normal population range. Family income may be associated with behavioral outcome. Glucocorticoid dose may reflect disease severity which may be associated with behavioral outcome. We conclude that internalizing behavioral problem was prevalent among boys with CAH reflecting maladaptive adjustment in coping with chronic illness. This highlighted the importance of psychological and social support for the patients and their families.
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spelling pubmed-39953142014-05-05 Behavioural Outcome in Children with Congenital Adrenal Hyperplasia: Experience of a Single Centre Idris, Arini Nuran Chandran, Viji Syed Zakaria, Syed Zulkifli Rasat, Rahmah Int J Endocrinol Research Article The aim of this study was to determine the behavioral outcome in children with CAH and to identify the risk factors that may influence it. Participants (aged 6–18 years) included 29 girls and 20 boys with CAH and unaffected siblings (25 girls and 17 boys). Psychological adjustment was assessed with parent reports on the Child Behavior Checklist (CBCL). Information about disease characteristics was obtained from medical records. Our study reveals that there was higher incidence of parent-reported problem of anxious/depressed and withdrawn/depressed behaviours, somatic complaints, social, thought, and attention problems, and rule-breaking, aggressive, internalizing, and externalizing behaviour among children with CAH compared to controls. The prevalence of internalizing behaviour problems was higher in CAH boys compared with that of controls. Psychosocial adjustment of girls with CAH was found to be similar to unaffected female controls and was within the normal population range. Family income may be associated with behavioral outcome. Glucocorticoid dose may reflect disease severity which may be associated with behavioral outcome. We conclude that internalizing behavioral problem was prevalent among boys with CAH reflecting maladaptive adjustment in coping with chronic illness. This highlighted the importance of psychological and social support for the patients and their families. Hindawi Publishing Corporation 2014 2014-04-01 /pmc/articles/PMC3995314/ /pubmed/24799898 http://dx.doi.org/10.1155/2014/483718 Text en Copyright © 2014 Arini Nuran Idris et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Idris, Arini Nuran
Chandran, Viji
Syed Zakaria, Syed Zulkifli
Rasat, Rahmah
Behavioural Outcome in Children with Congenital Adrenal Hyperplasia: Experience of a Single Centre
title Behavioural Outcome in Children with Congenital Adrenal Hyperplasia: Experience of a Single Centre
title_full Behavioural Outcome in Children with Congenital Adrenal Hyperplasia: Experience of a Single Centre
title_fullStr Behavioural Outcome in Children with Congenital Adrenal Hyperplasia: Experience of a Single Centre
title_full_unstemmed Behavioural Outcome in Children with Congenital Adrenal Hyperplasia: Experience of a Single Centre
title_short Behavioural Outcome in Children with Congenital Adrenal Hyperplasia: Experience of a Single Centre
title_sort behavioural outcome in children with congenital adrenal hyperplasia: experience of a single centre
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995314/
https://www.ncbi.nlm.nih.gov/pubmed/24799898
http://dx.doi.org/10.1155/2014/483718
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