Cargando…
Effects of Stingless Bee Propolis on Experimental Asthma
Bee products have been used empirically for centuries, especially for the treatment of respiratory diseases. The present study evaluated the effect of treatment with a propolis hydroalcoholic extract (PHE) produced by Scaptotrigona aff. postica stingless bee in a murine asthma model. BALB/c mice wer...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995315/ https://www.ncbi.nlm.nih.gov/pubmed/24799946 http://dx.doi.org/10.1155/2014/951478 |
_version_ | 1782312861953949696 |
---|---|
author | de Farias, José Hidelbland Cavalcante Reis, Aramys Silva Araújo, Marcio Antonio Rodrigues Araújo, Maria José Abigail Mendes Assunção, Anne Karine Martins de Farias, Jardel Cavalcante Fialho, Eder Magalhães Silva Silva, Lucilene Amorim Costa, Graciomar Conceição Guerra, Rosane Nassar Meireles Ribeiro, Maria Nilce Sousa do Nascimento, Flávia Raquel Fernandes |
author_facet | de Farias, José Hidelbland Cavalcante Reis, Aramys Silva Araújo, Marcio Antonio Rodrigues Araújo, Maria José Abigail Mendes Assunção, Anne Karine Martins de Farias, Jardel Cavalcante Fialho, Eder Magalhães Silva Silva, Lucilene Amorim Costa, Graciomar Conceição Guerra, Rosane Nassar Meireles Ribeiro, Maria Nilce Sousa do Nascimento, Flávia Raquel Fernandes |
author_sort | de Farias, José Hidelbland Cavalcante |
collection | PubMed |
description | Bee products have been used empirically for centuries, especially for the treatment of respiratory diseases. The present study evaluated the effect of treatment with a propolis hydroalcoholic extract (PHE) produced by Scaptotrigona aff. postica stingless bee in a murine asthma model. BALB/c mice were immunized twice with ovalbumin (OVA) subcutaneously. After 14 days, they were intranasally challenged with OVA. Groups P50 and P200 received PHE by gavage at doses of 50 and 200 mg/kg, respectively. The DEXA group was treated with intraperitoneal injection of dexamethasone. The OVA group received only water. The mice were treated daily for two weeks and then they were immunized a second time with intranasal OVA. The treatment with PHE decreased the cell number in the bronchoalveolar fluid (BAL). Histological analysis showed reduced peribronchovascular inflammation after treatment with PHE especially the infiltration of polymorphonuclear cells. In addition, the concentration of interferon-γ (IFN-γ) in the serum was decreased. These results were similar to those obtained with dexamethasone. Treatment with S. aff postica propolis reduced the pathology associated with murine asthma due an inhibition of inflammatory cells migration to the alveolar space and the systemic progression of the allergic inflammation. |
format | Online Article Text |
id | pubmed-3995315 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39953152014-05-05 Effects of Stingless Bee Propolis on Experimental Asthma de Farias, José Hidelbland Cavalcante Reis, Aramys Silva Araújo, Marcio Antonio Rodrigues Araújo, Maria José Abigail Mendes Assunção, Anne Karine Martins de Farias, Jardel Cavalcante Fialho, Eder Magalhães Silva Silva, Lucilene Amorim Costa, Graciomar Conceição Guerra, Rosane Nassar Meireles Ribeiro, Maria Nilce Sousa do Nascimento, Flávia Raquel Fernandes Evid Based Complement Alternat Med Research Article Bee products have been used empirically for centuries, especially for the treatment of respiratory diseases. The present study evaluated the effect of treatment with a propolis hydroalcoholic extract (PHE) produced by Scaptotrigona aff. postica stingless bee in a murine asthma model. BALB/c mice were immunized twice with ovalbumin (OVA) subcutaneously. After 14 days, they were intranasally challenged with OVA. Groups P50 and P200 received PHE by gavage at doses of 50 and 200 mg/kg, respectively. The DEXA group was treated with intraperitoneal injection of dexamethasone. The OVA group received only water. The mice were treated daily for two weeks and then they were immunized a second time with intranasal OVA. The treatment with PHE decreased the cell number in the bronchoalveolar fluid (BAL). Histological analysis showed reduced peribronchovascular inflammation after treatment with PHE especially the infiltration of polymorphonuclear cells. In addition, the concentration of interferon-γ (IFN-γ) in the serum was decreased. These results were similar to those obtained with dexamethasone. Treatment with S. aff postica propolis reduced the pathology associated with murine asthma due an inhibition of inflammatory cells migration to the alveolar space and the systemic progression of the allergic inflammation. Hindawi Publishing Corporation 2014 2014-04-01 /pmc/articles/PMC3995315/ /pubmed/24799946 http://dx.doi.org/10.1155/2014/951478 Text en Copyright © 2014 José Hidelbland Cavalcante de Farias et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article de Farias, José Hidelbland Cavalcante Reis, Aramys Silva Araújo, Marcio Antonio Rodrigues Araújo, Maria José Abigail Mendes Assunção, Anne Karine Martins de Farias, Jardel Cavalcante Fialho, Eder Magalhães Silva Silva, Lucilene Amorim Costa, Graciomar Conceição Guerra, Rosane Nassar Meireles Ribeiro, Maria Nilce Sousa do Nascimento, Flávia Raquel Fernandes Effects of Stingless Bee Propolis on Experimental Asthma |
title | Effects of Stingless Bee Propolis on Experimental Asthma |
title_full | Effects of Stingless Bee Propolis on Experimental Asthma |
title_fullStr | Effects of Stingless Bee Propolis on Experimental Asthma |
title_full_unstemmed | Effects of Stingless Bee Propolis on Experimental Asthma |
title_short | Effects of Stingless Bee Propolis on Experimental Asthma |
title_sort | effects of stingless bee propolis on experimental asthma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995315/ https://www.ncbi.nlm.nih.gov/pubmed/24799946 http://dx.doi.org/10.1155/2014/951478 |
work_keys_str_mv | AT defariasjosehidelblandcavalcante effectsofstinglessbeepropolisonexperimentalasthma AT reisaramyssilva effectsofstinglessbeepropolisonexperimentalasthma AT araujomarcioantoniorodrigues effectsofstinglessbeepropolisonexperimentalasthma AT araujomariajoseabigailmendes effectsofstinglessbeepropolisonexperimentalasthma AT assuncaoannekarinemartins effectsofstinglessbeepropolisonexperimentalasthma AT defariasjardelcavalcante effectsofstinglessbeepropolisonexperimentalasthma AT fialhoedermagalhaessilva effectsofstinglessbeepropolisonexperimentalasthma AT silvalucileneamorim effectsofstinglessbeepropolisonexperimentalasthma AT costagraciomarconceicao effectsofstinglessbeepropolisonexperimentalasthma AT guerrarosanenassarmeireles effectsofstinglessbeepropolisonexperimentalasthma AT ribeiromarianilcesousa effectsofstinglessbeepropolisonexperimentalasthma AT donascimentoflaviaraquelfernandes effectsofstinglessbeepropolisonexperimentalasthma |