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Pterygium: Nonsurgical Treatment Using Topical Dipyridamole – A Case Report

PURPOSE: We report a case of a symptomatic, inflamed pterygium treated nonsurgically with topical dipyridamole and followed for 12 months. CASE REPORT: A 35-year-old woman presented with a stage II to III, V3, C3, K2, P1 (using Johnston, Williams & Sheppard's classification) pterygium in he...

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Autores principales: Carlock, Beth H., Bienstock, Carol A., Rogosnitzky, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995373/
https://www.ncbi.nlm.nih.gov/pubmed/24761148
http://dx.doi.org/10.1159/000362113
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author Carlock, Beth H.
Bienstock, Carol A.
Rogosnitzky, Moshe
author_facet Carlock, Beth H.
Bienstock, Carol A.
Rogosnitzky, Moshe
author_sort Carlock, Beth H.
collection PubMed
description PURPOSE: We report a case of a symptomatic, inflamed pterygium treated nonsurgically with topical dipyridamole and followed for 12 months. CASE REPORT: A 35-year-old woman presented with a stage II to III, V3, C3, K2, P1 (using Johnston, Williams & Sheppard's classification) pterygium in her right eye. She complained of a foreign body sensation, dryness, burning, and persistent uncontrolled blinking. A raised lesion was observed on the nasal conjunctiva that was 1.5 mm in size. It extended slightly onto the nasal cornea. There was moderate vascularity of the lesion that obscured the underlying scleral vessels. Moderate conjunctival hyperemia was detected at and medial to the pterygium. The cornea, anterior chamber, and external anatomy were otherwise unremarkable. The eye was initially treated twice daily with a topical application of dipyridamole in a normal saline solution, which was later reduced to once daily. RESULTS: There was a marked improvement in both the pterygium and the patient's symptoms. The tissue regressed from the limbal region of the cornea, had decreased in length from 1.5 to 1.0 mm, and decreased in height from approximately 1.0 to approximately 0.3 mm. Conjunctival hyperemia and vascularization resolved completely, and the underlying scleral vessels could once again be visualized. At 12 months, the pterygium was graded as stage 0 to I, V0, C2, K0, P0. CONCLUSIONS: To our knowledge, this is the first case of successful management of a pterygium and associated symptoms using topical dipyridamole. Further investigation is required to clarify the potential role of dipyridamole in the treatment of pterygia and pingueculae.
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spelling pubmed-39953732014-04-23 Pterygium: Nonsurgical Treatment Using Topical Dipyridamole – A Case Report Carlock, Beth H. Bienstock, Carol A. Rogosnitzky, Moshe Case Rep Ophthalmol Published online: March, 2014 PURPOSE: We report a case of a symptomatic, inflamed pterygium treated nonsurgically with topical dipyridamole and followed for 12 months. CASE REPORT: A 35-year-old woman presented with a stage II to III, V3, C3, K2, P1 (using Johnston, Williams & Sheppard's classification) pterygium in her right eye. She complained of a foreign body sensation, dryness, burning, and persistent uncontrolled blinking. A raised lesion was observed on the nasal conjunctiva that was 1.5 mm in size. It extended slightly onto the nasal cornea. There was moderate vascularity of the lesion that obscured the underlying scleral vessels. Moderate conjunctival hyperemia was detected at and medial to the pterygium. The cornea, anterior chamber, and external anatomy were otherwise unremarkable. The eye was initially treated twice daily with a topical application of dipyridamole in a normal saline solution, which was later reduced to once daily. RESULTS: There was a marked improvement in both the pterygium and the patient's symptoms. The tissue regressed from the limbal region of the cornea, had decreased in length from 1.5 to 1.0 mm, and decreased in height from approximately 1.0 to approximately 0.3 mm. Conjunctival hyperemia and vascularization resolved completely, and the underlying scleral vessels could once again be visualized. At 12 months, the pterygium was graded as stage 0 to I, V0, C2, K0, P0. CONCLUSIONS: To our knowledge, this is the first case of successful management of a pterygium and associated symptoms using topical dipyridamole. Further investigation is required to clarify the potential role of dipyridamole in the treatment of pterygia and pingueculae. S. Karger AG 2014-03-25 /pmc/articles/PMC3995373/ /pubmed/24761148 http://dx.doi.org/10.1159/000362113 Text en Copyright © 2014 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: March, 2014
Carlock, Beth H.
Bienstock, Carol A.
Rogosnitzky, Moshe
Pterygium: Nonsurgical Treatment Using Topical Dipyridamole – A Case Report
title Pterygium: Nonsurgical Treatment Using Topical Dipyridamole – A Case Report
title_full Pterygium: Nonsurgical Treatment Using Topical Dipyridamole – A Case Report
title_fullStr Pterygium: Nonsurgical Treatment Using Topical Dipyridamole – A Case Report
title_full_unstemmed Pterygium: Nonsurgical Treatment Using Topical Dipyridamole – A Case Report
title_short Pterygium: Nonsurgical Treatment Using Topical Dipyridamole – A Case Report
title_sort pterygium: nonsurgical treatment using topical dipyridamole – a case report
topic Published online: March, 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995373/
https://www.ncbi.nlm.nih.gov/pubmed/24761148
http://dx.doi.org/10.1159/000362113
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