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Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study
BACKGROUND: Nuclear alterations are a well-known manifestation of cancer. However, little is known about the early, microscopically-undetectable stages of malignant transformation. Based on the phenomenon of field cancerization, the tissue in the field of a tumor can be used to identify and study th...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995586/ https://www.ncbi.nlm.nih.gov/pubmed/24629088 http://dx.doi.org/10.1186/1471-2407-14-189 |