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Multi-Parametric Spinal Cord MRI as Potential Progression Marker in Amyotrophic Lateral Sclerosis

OBJECTIVE: To evaluate multimodal MRI of the spinal cord in predicting disease progression and one-year clinical status in amyotrophic lateral sclerosis (ALS) patients. MATERIALS AND METHODS: After a first MRI (MRI(1)), 29 ALS patients were clinically followed during 12 months; 14/29 patients underw...

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Autores principales: El Mendili, Mohamed-Mounir, Cohen-Adad, Julien, Pelegrini-Issac, Mélanie, Rossignol, Serge, Morizot-Koutlidis, Régine, Marchand-Pauvert, Véronique, Iglesias, Caroline, Sangari, Sina, Katz, Rose, Lehericy, Stéphane, Benali, Habib, Pradat, Pierre-François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995720/
https://www.ncbi.nlm.nih.gov/pubmed/24755826
http://dx.doi.org/10.1371/journal.pone.0095516
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author El Mendili, Mohamed-Mounir
Cohen-Adad, Julien
Pelegrini-Issac, Mélanie
Rossignol, Serge
Morizot-Koutlidis, Régine
Marchand-Pauvert, Véronique
Iglesias, Caroline
Sangari, Sina
Katz, Rose
Lehericy, Stéphane
Benali, Habib
Pradat, Pierre-François
author_facet El Mendili, Mohamed-Mounir
Cohen-Adad, Julien
Pelegrini-Issac, Mélanie
Rossignol, Serge
Morizot-Koutlidis, Régine
Marchand-Pauvert, Véronique
Iglesias, Caroline
Sangari, Sina
Katz, Rose
Lehericy, Stéphane
Benali, Habib
Pradat, Pierre-François
author_sort El Mendili, Mohamed-Mounir
collection PubMed
description OBJECTIVE: To evaluate multimodal MRI of the spinal cord in predicting disease progression and one-year clinical status in amyotrophic lateral sclerosis (ALS) patients. MATERIALS AND METHODS: After a first MRI (MRI(1)), 29 ALS patients were clinically followed during 12 months; 14/29 patients underwent a second MRI (MRI(2)) at 11±3 months. Cross-sectional area (CSA) that has been shown to be a marker of lower motor neuron degeneration was measured in cervical and upper thoracic spinal cord from T2-weighted images. Fractional anisotropy (FA), axial/radial/mean diffusivities (λ(⊥), λ(//), MD) and magnetization transfer ratio (MTR) were measured within the lateral corticospinal tract in the cervical region. Imaging metrics were compared with clinical scales: Revised ALS Functional Rating Scale (ALSFRS-R) and manual muscle testing (MMT) score. RESULTS: At MRI(1), CSA correlated significantly (P<0.05) with MMT and arm ALSFRS-R scores. FA correlated significantly with leg ALFSRS-R scores. One year after MRI(1), CSA predicted (P<0.01) arm ALSFSR-R subscore and FA predicted (P<0.01) leg ALSFRS-R subscore. From MRI(1) to MRI(2), significant changes (P<0.01) were detected for CSA and MTR. CSA rate of change (i.e. atrophy) highly correlated (P<0.01) with arm ALSFRS-R and arm MMT subscores rate of change. CONCLUSION: Atrophy and DTI metrics predicted ALS disease progression. Cord atrophy was a better biomarker of disease progression than diffusion and MTR. Our study suggests that multimodal MRI could provide surrogate markers of ALS that may help monitoring the effect of disease-modifying drugs.
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spelling pubmed-39957202014-04-25 Multi-Parametric Spinal Cord MRI as Potential Progression Marker in Amyotrophic Lateral Sclerosis El Mendili, Mohamed-Mounir Cohen-Adad, Julien Pelegrini-Issac, Mélanie Rossignol, Serge Morizot-Koutlidis, Régine Marchand-Pauvert, Véronique Iglesias, Caroline Sangari, Sina Katz, Rose Lehericy, Stéphane Benali, Habib Pradat, Pierre-François PLoS One Research Article OBJECTIVE: To evaluate multimodal MRI of the spinal cord in predicting disease progression and one-year clinical status in amyotrophic lateral sclerosis (ALS) patients. MATERIALS AND METHODS: After a first MRI (MRI(1)), 29 ALS patients were clinically followed during 12 months; 14/29 patients underwent a second MRI (MRI(2)) at 11±3 months. Cross-sectional area (CSA) that has been shown to be a marker of lower motor neuron degeneration was measured in cervical and upper thoracic spinal cord from T2-weighted images. Fractional anisotropy (FA), axial/radial/mean diffusivities (λ(⊥), λ(//), MD) and magnetization transfer ratio (MTR) were measured within the lateral corticospinal tract in the cervical region. Imaging metrics were compared with clinical scales: Revised ALS Functional Rating Scale (ALSFRS-R) and manual muscle testing (MMT) score. RESULTS: At MRI(1), CSA correlated significantly (P<0.05) with MMT and arm ALSFRS-R scores. FA correlated significantly with leg ALFSRS-R scores. One year after MRI(1), CSA predicted (P<0.01) arm ALSFSR-R subscore and FA predicted (P<0.01) leg ALSFRS-R subscore. From MRI(1) to MRI(2), significant changes (P<0.01) were detected for CSA and MTR. CSA rate of change (i.e. atrophy) highly correlated (P<0.01) with arm ALSFRS-R and arm MMT subscores rate of change. CONCLUSION: Atrophy and DTI metrics predicted ALS disease progression. Cord atrophy was a better biomarker of disease progression than diffusion and MTR. Our study suggests that multimodal MRI could provide surrogate markers of ALS that may help monitoring the effect of disease-modifying drugs. Public Library of Science 2014-04-22 /pmc/articles/PMC3995720/ /pubmed/24755826 http://dx.doi.org/10.1371/journal.pone.0095516 Text en © 2014 El Mendili et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
El Mendili, Mohamed-Mounir
Cohen-Adad, Julien
Pelegrini-Issac, Mélanie
Rossignol, Serge
Morizot-Koutlidis, Régine
Marchand-Pauvert, Véronique
Iglesias, Caroline
Sangari, Sina
Katz, Rose
Lehericy, Stéphane
Benali, Habib
Pradat, Pierre-François
Multi-Parametric Spinal Cord MRI as Potential Progression Marker in Amyotrophic Lateral Sclerosis
title Multi-Parametric Spinal Cord MRI as Potential Progression Marker in Amyotrophic Lateral Sclerosis
title_full Multi-Parametric Spinal Cord MRI as Potential Progression Marker in Amyotrophic Lateral Sclerosis
title_fullStr Multi-Parametric Spinal Cord MRI as Potential Progression Marker in Amyotrophic Lateral Sclerosis
title_full_unstemmed Multi-Parametric Spinal Cord MRI as Potential Progression Marker in Amyotrophic Lateral Sclerosis
title_short Multi-Parametric Spinal Cord MRI as Potential Progression Marker in Amyotrophic Lateral Sclerosis
title_sort multi-parametric spinal cord mri as potential progression marker in amyotrophic lateral sclerosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995720/
https://www.ncbi.nlm.nih.gov/pubmed/24755826
http://dx.doi.org/10.1371/journal.pone.0095516
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